Mondy Wk 4 Rheum Flashcards
low levels of C1 esterase inhibs is __ dx
AD cx w episodes of painless, well circumscribed painless __
usually involves face but can affect TB tree w obstruction and __ or GI tract w diarrhea
C1 esterase degrades __ to downregulate complement
inactivates K__ which inc prodxn of bradkyinin
def of C1 esterase thus has bradykinin, C3a, C5a __ to inc VD and vasc permeability
C4 will be __
angioedema is comp of __ exacerbating bradykinin accumulation
do not use in pt w __
hereditary angioedema edema Resp distress C1 complement kallkrein accumulate low
ACEI
HA
immune complex vasculitis w IgA/C3 deposition always indicates H__
comps of reactive arthritis include keratoderma B__ and circinate B__
HBV causes damage as antigens are presented to MHC class _ to activate CD8 t cells to destroy host lymphocytes
Dyspnea, hypoTN, tachycardia after B lactam indicates __ shock
hypoTN due to collapse of __ inc vasc permeability and leaking capillary fluid
inc bronchial wall tone/__ prodxn leads to SOB
skin sx due to __ and inc permeability
tx w __ as it stimulates A1, B1, B2 receptors
henoch schonlein purpura
blenorrhagica, balanitus
1
anaphylactic PVR mucus VD Epinephrine
use 2nd gen antihistamines like C, L in elderly pt
C1 INH def can be acquired/hereditary resulting in ___
due to elevated __
not assc w __/__
tx w admin __ concentrate
scarlet fever due to GAS w __ exotoxin
produces rash in N/A/G that spreads to rest of body
may have __ appearance and flushed cheeks w sparing of mouth
Roseola rash begins on _
cimetidine, loratidine
angioedema
braykinin
urticaria/pruritis
C1INH
pyrogenic
necks, axilla, groin
sandpaper
trunk
spleen capillaries are open ended/sinusoidal allowing for blood to enter __ cord
act as a sieve to pass through __ and ingest matter
important to destroy aged/abnormal __ and store RBC/platelets
clear circulating __ as macros present antigens to B/T cells to mount response
majority of Ig are produced by seplenic __
splenic __ antibody is important to clear encapsulated species
__ is site for complement prodxn
Type 1 interferons __/__ are released by cells in response to viral infection
these bind receptors to stop __ synthesis
such as RNase _ to degrade RNA or protein kinase _ to stop translation)
only active in presence of ds__ thus uninfected cells are normal
mechanism is P/A signaling
also inc __ expression on all cells to stimulate apoptosis
red pulp macros RBC bacteria B cells opsonizing
Liver
Alpha/beta protein L, R RNA paracrine, autocrine
MHC class 1
Tx diptheria w Diptheria __ for passive immunization bc it is preexisting, neutralizing AA
not effective against toxin that has infected __/__ cells
then P/E to kill bacteria
then DPT __
__ is MCC of death
IFNG produced by __/__
IGRA assay tests for latent __ infection by measuring T cells exposed
measure of __ like PPD
cannot differentiate __/__ infection
look for sx and __ CXR and positive sputum smear
antitoxin cardiac/neural penicillin, erythromycin vaccine Cardiomyopathy
T cells, NK cells Tb CMI active/latent abnormal
anaphylactic rxn is type __ w multisystem edema as fluid shifts from __ to extravascular compartment
due to __/__ degranulation w release of histamine/tryptase
Tryptase is specific to __
vaso__ w hypoTN and edema
tachy__
upper aiway edema w __/__
bronchospasm and w__
urticaria, pruritis, NV and __ pain
tx w Epi, __ mx and volume resus, and adjunct therapy
1, intravascular
MC, basophil
mast cells
dilation
cardia
stridor, hoarseness
wheezing
ab
airway
IgE receptor on MC/basos binds __ portion of IgE
when multiple antibodies become cross linked, A__ results in activation of nonreceptor TK w MC/basophil __
Calcineurin is protein phosphatase that dephosphorylates __ to allow it to enter the nucleus and inc IL2 prodxn
C/T are calcineurin inhibs to dec this t cell activation
recurrent sinopulm, GI infections, lack of signaling bw CD4 and B cells is __ dx
inheritance is __
class switching occurs via _ out codin of heavy chain constant region
V__ region stays as it carries antigen specificity
Fc
aggregation
degranulation
NFAT
cyclosporine, tacrolimus
hyperIgM (CD40L def)
XL R
splicing
variable
SCID shows lymphopenia and hypo__
use __ antigen to determine if CMI fxn is present
failure to generate a response indicates A__
NADPH oxidase def presents w diffuse __ formation
can evaluate w NBT which should appear __
or DHR__ flow cytometry which should turn green in presence of __
inheritance is __
Myeloperoxidase def will have __ tests
pt w acute febrile syndrome post pen G tx for syphillis has __ rxn
caused by antibitoic lysis of __ spilling contents into blood
gammaglobulinemia
candida
anergy
granuloma
dark blue
dihydrorhodamine
superoxide
normal
Jarisch Herxheimer
spirochetes
O__ is when host proteins bind to surface of foreign cells and promote phagocytosis
occurs via __/__
as opsonins bind cell surface, they act as handle for __ to grasph and engulf
C3 is activated in all __ pathways
thus, C3b is a necessary __
IgM does not directly activate __
__rejection occurs when organ is immediately cyanotic and mottled
due to __ mediated rxn w preformed IgG (Type 2 HS)
vasc wall thickening/luminal narrowing w interstital fibrosis and parenchymal atrophy indicates __ rejection
necrotizing vasc/infiltration indicates acute __ reject
opsonization
IgG, C3b
phagosomes
complement
opsonin
phagocytosis
hyperacute
antibody
hyperacute
humoral
thymic hypoplasia can also be seen in __
must look for other sx of __ like hypoCa and heart probs
CVID is __/__ cell dysfxn w hypogammaglobulinemia
CMI is not perfect but is relatively __
Hib vaccine is conj to __ toxin or __ of N men
Type 1 HS rxn produces H, T, L, prostaglandins
polysaccharide vaccines are not __ in children less than 2 due to immature humoral antibody response
Rotavirus and Varicella virus are example of __ vaccines
nasal ulceration, sinusitis, hemoptysis and glomerulonephritis indicates __
SCID
Di George
B/T
unaffected
Tetanus, OMP
histamine, tryptase, leukotrienes
immunogenic
live attenuated
GPA
