Neuro 6 Flashcards

1
Q

viral encephalitis is usually due to __
look for F/HA/stiff neck

gram stain/culture should be __

if parotitis is present, then virus may be ___

A

enterovirus

negative

mumps

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2
Q

middle ear cavity contains M/I/S and TT/S

stapedius is innervated by __ nerve, branch of CN 7

paralysis of stapedius leads to stapes oscillating widely, resulting in __
pt is very sensitive to __ sounds

__ muscle arises from cartilage portion of auditory tube, inserting to __
contracts __, inc tension and dampening ___
innervated by CN __ (_ portion)

hyperacusis can present w __

A

malleus, incus, stapes

tensor tympani, stapedius

stapedius

hypeacusis
everyday

TT, malleus
tympanic membrnae, sound
V3, mandibular

Bell palsy

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3
Q

B12 deficiency results in destruxn of __/__ tracts

leads to loss of __/__ w __ paresis

A

dorsal column, lateral CS

prop/vibration, spastic

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4
Q

__ is most common neuro disorder affecting kids

see seizure w high __
__ is tx
antipyretics like A/I inhibit __ synthesis
lowers __

__ is contraindicated, as it can raise __

use active cooling for __

A

febrile seizuee

temp
supportive care
acetominophen/ibuprofen
PGE2
temp

active cooling, body temp

heat stroke

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5
Q

__ is AR disorder of ashkenazi jews
deficiency in ___, results in accumulation of __ w/in lysosomes

progressive neuro dys as __ accumulate in brain
weak, seizure, blind, spastic
PE shows abnormal __ reflex and M, __ macula spot

losss of retinal transparency due to __ buildup in ganglion cels

A

Tay Sachs
B hexosaminidase, GM2 ganglioside

glycolipids
startle, macrocephaly, cherry red macula

ganglioside

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6
Q

__ disease has galactocerebroside accumulate
progressive neuro degen w __ neuropathy and __ atrophy

__ disease is globotriaosylceramide accumulation
see angiokeratoma, __ and __

__ disease has B glucocerebrosidase accumulation and hepatomegaly

Niemann pick has __ accumulation and similar presentation but w __

A

Krabbe, peripheral, optic

Fabry, PN, glomerulopathy

Gaucher

sphinomyelin, HM

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7
Q

__ disease is deficient in G6Pase
HM, hypoGly, and __

__ disease is lysosomal a 1/4 glucosidase def
see cardiomegaly and hypotonia

Mucopolysaccharidoses include __/__ syndrome
see __ accumulate w coarse facies/skeletal abnorms

A

Von gierke, LA

Pompe

Hunter/hurler
GAG

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8
Q

entacapone is a __ that inhibits peripheral methylation of LDOPA

_ is common cause of rapid onset sepsis/circ collapse in otherwise healthy indiv

look for __/__ rash due to DIC

severity of dz due to __, an endotoxin upon bacterial lysis

bind to TLR 4, causing release of inflam cytokines __/__/__
leads to __ damage, __ leakage, __ necrosis

A

COMT

N men

petechiae/ecchymotic

LOS

Il1/IL6/TNF
endothelial, capillary, hemorrhagic

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9
Q

__ is 1st line, __ is second line for absence seizures

phenytoin prvents Na channels from recovering from ___
Carb/valproic block __ Na channels

A

ethosuximide, valproic acid

inactivation
voltage gated

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10
Q

__ is a brain tumor w whorled pattern of cells
can have __ bodies
occur at __/__ region of brain
can have __ w compression of ceberal cortex
Ha/N/V all other SE due to __ that worsens w ___

__ is a suprasellar tumor in kids
cords/nest of palisading __ epithelium

__ is a malignant tumor in adults w atypical __ forming pseudopalisading cells

__ involves white matter of cerebra hemispheres
has __ appearance

A
meningioma
psamomma
falcine/parasagittal
seizure
inc ICP, recumbency

craniopharyngioma
squamous

glioblastoma

oliodendrogliomas

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11
Q

NF caused by mutation in NF1 gene on chromosome __
may have __ gliomas
spenoid __, pseudo__
also assc w __

A

17
optic nerve
dysplasia, arthrosis
brain tumors

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12
Q

__ blocks voltage gated sodium channels in partial/generalized seizures
SE is rash of __/__
may have __ sx

look for epidermal __

SJS/TEN also seen w C/P/P

A

lamontrigine
SJS/TEN
flu like

necrosis

carbamezipine, phenytoin, phenobarbitol

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13
Q

acute onset of neuro sx like weakness, blindess, diplopia, seizure w stress is __ dx

lack of voluntary __/__ function w/out actual problems

patient will be __ to sx

factitious do patient like the __ role

A

conversion do

motor/sensory

indifferent

sick role

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14
Q

__ contains C5-T1 spinal nerves
passes bw __/__ scalenes in posterior neck

interscalene nerve block used for anesthesia for __ procedure to block BP
can lead to ipsi __ paralysis due to phrenic nerve

avoid in patient w ___ or __ phrenic nerve dysfxn

A

brachial plexus
medial/anterior

shoulder
diaphragmatic

CLD, contra

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15
Q

Craniopharyngioma is __ or partially __
filled w brown/yellow fluid due to presence of __ crystals

dystrophic __ of cysts is characteristic

derived from remnant of __ lining oral cavity
protrusion of roof of mouth forms ___

PP is an outpouching of __ from neuroectoderm

A

cystic, cystic
cholesterol

calcification

rathke pouch
AP

diencephalon

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16
Q

__ is measure of how far along axon elecrical impulse can propagate

myelin dec __ therefore inc ___
thus demyelination __ length constant

__ is additive effects of multiple PS potentials
occurs at D/cell __/axon __
__ is same neuron firing
__ is simultaneous firing from several neurons

__ is time it takes for membrane potential to change
myelination __ membrane capacitance, so demyelination __ time constant

A

length constant

charge dissipation, length constant
dec

summation
dendrite, cell body, axon hillock
temporal
sptaila

time constant
dec, inc

17
Q

congenital __ presents w macrocephaly and poor feeding
untx can lead to __ injury and spasticity due to stretching of __ pyramidal tracts

tx w __ placement

A

hydrocephalus
UMN
periventricular

18
Q

__ is paired pigmented brainstem nuclei in rostral pons near lateral floor of 4th ventricle

principal site for __ prodxn
important for M/A (RF)/ sleep-wake, C and autonomic fxn

abnormal activation can lead to __ disorders

A

locus ceruleus

NE
mood, arousal, cognition

anxiety

19
Q

__ is produced in ventral tegmental area/SNPC in midbrain

__ modulates pain
found in periaqueductal gry, RVM, and dorsal horn of SC

NE converted to __ in AM

H/O produced in posterior hypothalamus

A

Dopamine

dynorphin

Epi

histamine, orexin

20
Q

__ disease involves the TMJ
affects muscles of __ and nerves supplying the __, __ ear
CN V3 is __
can have __/__ sx

maxillary division of CNV2 is only ___

A

temporomandivular
mastication, jaw, middle
mandibular division
jaw/ear

sensory

21
Q

__ deficiency can occur w hemolysis and neuro dysfxn
may mimic __

ataxia due to __ damage
lost position/vibration due to __damage
lost DTR due to __ damage

A

VE
Friedrich ataxia

SC tract
dorsal column
PN

22
Q

damage to brainstem below red nucleus (ie pons/midbrain) leads to decerebrate __ posturing

damage above red nucleus (cerebral hemispheres/IC) leads to decorticate __ posturing

A

extensor

flexor

23
Q

uncal hearniation can lead to brainstem compression and Cushing triad
B/H/R

leads to palsy of CN __
over time, pupil becomes __/__

A

bradycardia, HTN, RDS

3
mid dilated, fixed