Structure of HAEMOGLOBIN and Oxyhaemoglobin dissociation curves.

Question 1

What is the affinity of haemoglobin for oxygen?

Answer 1

= ability of haemoglobin to bind/attact to oxygen

Question 2

What is the saturation of haemoglobin with oxygen?

Answer 2

= when haemoglobin is holding the maximum amount of oxygen it can bind to

Question 3

What is the loading/association of haemoglobin?

Answer 3

= the binding of oxygen to haemoglobin

Question 4

What is unloading and dissociating of haemoglobin?

Answer 4

= when oxygen detaches or unbinds from haemoglobin

Question 5

What is the oxyhaemoglobin dissociative curve?

Answer 5

= s shaped curve
= oxygen is loaded in regions of high partial pressure of oxygen (concentration), haemoglboin is saturated with oxygen- higher affinity of oxygen
= at lower partial pressure, there is a low saturatin- haemoglobin does not have as high of an affinity
= unload oxygen in these regions- easier to unload

Question 6

Where would there be a low partial pressure of oxygen?

Answer 6

= respiring tissues
= there would be a lower affinity of oxygen as there is a low partial pressure of oxygen
= allows oxygen to be unloaded/dissociate, in where it is neeeded

Question 7

Where would there be a high partial pressure of oxygen?

Answer 7

= alveoli
= loading/associating oxygen
= high partial pressure
=

Question 8

What is cooperative binding?

Answer 8

= it is difficult for the first oxygen to bind to haemoglobin
= it makes it easier when binding occus as:
= haemiglvoin is a protein
= haemoglobin changes quaternary strucure to expose the adjacent haem groups to allow oxygen to easily bind to it

Question 9

What is the bohr affect?

Answer 9

= when a high concentration of carbon dioxide - this will form carbonic acid when dissolved in water in blood, blood becomes acidic
= oxyheamogloboin curves shifts to the right
= haemiglobin affinity of oxygen decrease- will readily unload oxygen
=

Question 10

What is the least acidic conditions like?

Answer 10

= lower partial pressure of carbon dioxide in alvelioli
= co2 diffuses out of the blood stream
= curve shifts to the left- haemoglobin has a higher affinity for oxygen so uploads oxygen
=

Question 11

What are the most acidic conditions like?

Answer 11

= curve shifted to thr right
= high partial pressure of carbon dioxide at respiring tissues
= curve shifts to the right- decreased affinity for haemoglobin and unloads more oxygen

Question 12

What do different animal types have?

Answer 12

= animals have different types of haemoglobin which have different affinities for oxygen which is adapted for their environment

Question 13

What is fetal haemoglobin like?

Answer 13

= `