Topography of the Brain Flashcards
… - development of the brain
Neurulation - development of the brain
Neurulation - development of the brain
- Embryonic day …
- Neuroectoderm cells receive inductive signals from …
- Cells thicken to form neural … - early NS
- Lateral neural plate margins fold inwards to form neural …
- Embryonic day 20
- Neuroectoderm cells receive inductive signals from notochord
- Cells thicken to form neural plate - early NS
- Lateral neural plate margins fold inwards to form neural tube
Neurulation - development of the brain
- Embryonic day 20
- Neuroectoderm cells receive inductive signals from notochord
- Cells thicken to form neural … - early NS
- Lateral neural plate margins fold inwards to form neural tube
- Embryonic day 20
- Neuroectoderm cells receive inductive signals from notochord
- Cells thicken to form neural plate - early NS
- Lateral neural plate margins fold inwards to form neural tube
… forms primitive nervous system
Ectoderm forms primitive nervous system
Running along the whole length of mesoderm is a rod like structure known as the noto…
Running along the whole length of mesoderm is a rod like structure known as the notochord
The Neural tube forms around day …
Neural tube - day 20
Neural tube - has neural crest cells
- These differentiate into 4 different types:
- Autonomic and sensory neurons and glia
- Cells of the … gland
- Epidermis
- …/connective tissue of the head
Neural tube - has neural crest cells
- These differentiate into 4 different types:
- Autonomic and sensory neurons and glia
- Cells of the adrenal gland
- Epidermis
- Skeletal/connective tissue of the head
Neural crest cells migrate into periphery and differentiate into 4 types and neural tube thickens - All around embryonic day …
Neural crest cells migrate into periphery and differentiate into 4 types and neural tube thickens - All around embryonic day 24
Neurulation
- The nervous system develops when the notochord induces its overlying ectoderm to become neuroectoderm and to develop into the neural …. The neural … folds along its central axis to form a neural groove lined on each side by a neural fold. The two neural folds fuse together and pinch off to become the neural …
- The nervous system develops when the notochord induces its overlying ectoderm to become neuroectoderm and to develop into the neural plate. The neural plate folds along its central axis to form a neural groove lined on each side by a neural fold. The two neural folds fuse together and pinch off to become the neural tube.
The bulk of our neural tube is called the …layer
The bulk of our neural tube is called the mantle layer - this becomes the brain parenchyma
The mantle layer of the neural tube becomes the brain …
parenchyma
Ependymal layer of the neural tube lines the …
ventricles of adult nervous system
The lumen of the neural tube becomes the … and … canal of our spinal cord
The lumen of the neural tube becomes the ventricles and central canal of our spinal cord
What day of neuralation does the neural tube thicken?
neural tube thickens - All around embryonic day 24
Neural tube defects occur in about 1 in every … established pregnancies
Neural tube defects occur in about 1 in every 1000 established pregnancies
Failure of the anterior neuropore to close means … will develop
anencephaly (Fatal) - less common
Failure of the posterior neuropore to close means … will develop
Failure of the posterior neuropore to close means Spina bifida will develop (divided by a cleft)
Anencephaly - … herniates out of foetus - degeneration of … - fatal
Anencephaly - Forebrain herniates out of foetus - degeneration of forebrain - fatal
Spina Bifida - … aspect fails to close - divided by a cleft - open vertebral canal
Spina Bifida - posterior aspect fails to close - divided by a cleft - open vertebral canal
2 types of SB : … (hidden, vertebral arch defect only) or … (e.g. meningocele = meninges projects out)
2 types of SB : occulta (hidden, vertebral arch defect only) or cystica (e.g. meningocele = meninges projects out)
Risk of neural tube defects is decreased by taking what during pregnancy?
folic acid
Primary Brain Vesicles
- P…
- M…
- R…
- Prosencephalon
- Mesencephalon
- Rhombencephalon
- Prosencephalon form the …
- Mesencephalon form the …
- Rhombencephalon form the …
- Prosencephalon form the forebrain
- Mesencephalon form the midbrain
- Rhombencephalon form the hindbrain
Development of the flexures (brain)
- 2 flexures:
- … flexure (near mesencephalon)
- … flexure (between rhombencephalon and spinal cord)
- 2 flexures:
- Cephalic flexure (near mesencephalon)
- Cervical flexure (between rhombencephalon and spinal cord)
Secondary brain vesicles
- Day … - primary vesicles have divided to form secondary brain vesicles
- Prosencephalon - divides into … and diencephalon
- Mesencephalon - forms midbrain (no divisions)
- Rhomencephalon - divides into … and myelencephalon
- Day 36 - primary vesicles have divided to form secondary brain vesicles
- Prosencephalon - divides into telencephalon and diencephalon
- Mesencephalon - forms midbrain (no divisions)
- Rhomencephalon - divides into metencephalon and myelencephalon
Secondary brain vesicles
- Day 36 - primary vesicles have divided to form secondary brain vesicles
- Prosencephalon - divides into telencephalon and …
- Mesencephalon - forms … (no divisions)
- Rhomencephalon - divides into metencephalon and myelencephalon
- Day 36 - primary vesicles have divided to form secondary brain vesicles
- Prosencephalon - divides into telencephalon and diencephalon
- Mesencephalon - forms midbrain (no divisions)
- Rhomencephalon - divides into metencephalon and myelencephalon
Prosencephalon
- Diivides into telencephalon (forms … …) and diencephalon (forms … and …)
- Diivides into telencephalon (forms cerebral hemispheres) and diencephalon (forms thalamus and hypothalamus)
Prosencephalon
- Diivides into … (forms cerebral hemispheres) and … (forms thalamus and hypothalamus)
- Diivides into telencephalon (forms cerebral hemispheres) and diencephalon (forms thalamus and hypothalamus)
Mesencephalon
- Does it divide?
no - forms midbrain
Rhombencephalon
- Divides into … (forms pons, cerebellum) and … (forms medulla)
- Divides into metencephalon (forms pons, cerebellum) and myelencephalon (forms medulla)
Rhombencephalon
- Divides into metencephalon (forms …, …) and myelencephalon (forms …)
- Divides into metencephalon (forms pons, cerebellum) and myelencephalon (forms medulla)
… flexure forces the cerebellum posterior to the brain stem
Pontine flexure forces the cerebellum posterior to the brain stem
Adult Brain
- Forebrain (… - formed of telencephalon which forms … hemispheres and diencephalon which forms the … and … )
- Midbrain (Mesencephalon)
- Hindbrain (rhombencephalon - formed of metencephalon which forms the pons and cerebellum and myelencephalon which forms the medulla)
- Forebrain (prosencephalon - formed of telencephalon which forms cerebral hemispheres and diencephalon which forms the thalamus and hypothalamus )
- Midbrain (Mesencephalon)
- Hindbrain (rhombencephalon - formed of metencephalon which forms the pons and cerebellum and myelencephalon which forms the medulla)
Adult Brain
- Forebrain (… - formed of telencephalon which forms cerebral hemispheres and diencephalon which forms the thalamus and hypothalamus )
- Midbrain (Mesencephalon)
- Hindbrain (… - formed of metencephalon which forms the pons and cerebellum and myelencephalon which forms the …)
- Forebrain (prosencephalon - formed of telencephalon which forms cerebral hemispheres and diencephalon which forms the thalamus and hypothalamus )
- Midbrain (Mesencephalon)
- Hindbrain (rhombencephalon - formed of metencephalon which forms the pons and cerebellum and myelencephalon which forms the medulla)
Adult Brain
- Forebrain (prosencephalon - formed of … which forms cerebral hemispheres and … which forms the thalamus and hypothalamus )
- Midbrain (Mesencephalon)
- Hindbrain (rhombencephalon - formed of … which forms the pons and cerebellum and myelencephalon which forms the medulla)
- Forebrain (prosencephalon - formed of telencephalon which forms cerebral hemispheres and diencephalon which forms the thalamus and hypothalamus )
- Midbrain (Mesencephalon)
- Hindbrain (rhombencephalon - formed of metencephalon which forms the pons and cerebellum and myelencephalon which forms the medulla)
Grey and White Matter
- CNS is made up of grey and white matter
- Grey matter - mainly … … bodies - … on MRI
- White matter - mainly myelinated axons - … on MRI
- CNS is made up of grey and white matter
- Grey matter - mainly neuronal cell bodies - darker on MRI
- White matter - mainly myelinated axons - lighter on MRI
Grey and White Matter
- CNS is made up of grey and white matter
- Grey matter - mainly neuronal cell bodies - … on MRI
- White matter - mainly … axons - … on MRI
- CNS is made up of grey and white matter
- Grey matter - mainly neuronal cell bodies - darker on MRI
- White matter - mainly myelinated axons - lighter on MRI
Grey matter appears light or dark on MRI?
Grey matter appears darker (white appears lighter)
Main components of the telencephalon
- Comprises the … hemispheres/cerebral cortex, components of the … system and the … ganglia
- Comprises the cerebral hemispheres/cerebral cortex, components of the limbic system and the basal ganglia
Cerebral hemispheres:
- Label the 4 lobes
Cerebral Cortex - Grey matter
- … layer of cerebral hemispheres
- Folded to form … and …
- Outer layer of cerebral hemispheres
- Folded to form gyri and sulci
- … - hills
- … - valleys
- Gyri - hills
- Sulcus - valleys
… sulcus - Divides frontal from parietal lobe
Central sulcus - Divides frontal from parietal lobe
Precentral gyrus - … function
Precentral gyrus - motor function
Postcentral gyrus - … function
Postcentral gyrus - sensory function
… sulcus - Divides temporal from parietal lobe
Lateral sulcus - Divides temporal from parietal lobe
Functional areas of cortex
- Lobes have a motor or sensory function
- … lobe - primary motor cortex in the precentral gyrus
- Also motor speech area of Broco
- … lobe - somatosensory complex in the postcentral gyrus
- (pain, touch, proprioception)
- … lobe - visual cortex
- … lobe - auditory centres and Olfactory centres
- Separate out lateral sulcus - gustatory cortex (taste) + Insula
- Lobes have a motor or sensory function
-
Frontal lobe - primary motor cortex in the precentral gyrus
- Also motor speech area of Broco
-
Parietal lobe - somatosensory complex in the postcentral gyrus
- (pain, touch, proprioception)
- Occipital lobe - visual cortex
-
Temporal lobe - auditory centres and Olfactory centres
- Separate out lateral sulcus - gustatory cortex (taste) + Insula