Physiology of Hearing Flashcards
Functions of hearing
- Alerting to dangers
- Localising objects
- Recognition
- Communication via speech
The nature of sound
- Sounds are travelling pressure waves that propagate through air at about 340 m/s
- Sounds have two important attributes: … (measured in Hz) and … (measured in dB SPL), which varies with the square of pressure
- dB = 10 x log (Sound intensity / reference intensity) or:
- 20 x log (sound pressure / reference pressure)
- Sounds are travelling pressure waves that propagate through air at about 340 m/s
- Sounds have two important attributes: frequency (measured in Hz) and intensity (measured in dB SPL), which varies with the square of pressure
- dB = 10 x log (Sound intensity / reference intensity) or:
- 20 x log (sound pressure / reference pressure)
The range of human hearing
- Frequency range of human hearing: approximately 20-20,000 Hz
- Adults progressively lose … frequencies
- Intensity range of human hearing varies over 14 orders of magnitude
- Intensities > …db can lead to permanent hearing damage
- Frequency range of human hearing: approximately 20-20,000 Hz
- Adults progressively lose high frequencies
- Intensity range of human hearing varies over 14 orders of magnitude
- Intensities > 90dB can lead to permanent hearing damage
The peripheral auditory system
- … ear, … ear, … and auditory nerve (part of the V…th cranial nerve)
- Outer ear, middle ear, cochlea and auditory nerve (part of the VIIIth cranial nerve)
The peripheral auditory system
- Outer ear, … ear, … and … nerve (part of the VIIIth cranial nerve)
- Outer ear, middle ear, cochlea and auditory nerve (part of the VIIIth cranial nerve)
The Middle ear
- An impendence matching device: increases pressure - …x, by the ratio of tympanic membrane and oval window areas, and to a lesser extent by the lever action of the middle ear ossicles
- Prevents sound from being reflected back from the fluid-filled …
- An impendence matching device: increases pressure - 45x, by the ratio of tympanic membrane and oval window areas, and to a lesser extent by the lever action of the middle ear ossicles
- Prevents sound from being reflected back from the fluid-filled cochlea
The Middle ear
- An impendence matching device: increases … - 45x, by the ratio of tympanic membrane and oval window areas, and to a lesser extent by the lever action of the middle ear ossicles
- Prevents sound from being reflected back from the …-filled cochlea
- An impendence matching device: increases pressure - 45x, by the ratio of tympanic membrane and oval window areas, and to a lesser extent by the lever action of the middle ear ossicles
- Prevents sound from being reflected back from the fluid-filled cochlea
Otitis media (& glue ear)
- Infection or inflammation of … ear
- Usually self-limiting
- Common in …
- Often from upper respiratory tract infection
- Secretory form with effusion
- ‘Glue ear’ If chronic causes a conductive … …
- May need draining - … (little opening - insert into ear drum - drain)
- Infection or inflammation of middle ear
- Usually self-isolating
- Common in children
- Often from upper respiratory tract infection
- Secretory form with effusion
- ‘Glue ear’ If chronic causes a conductive hearing loss
- May need draining - grommets (little opening - insert into ear drum - drain)
Otitis media (& glue ear)
- … or … of middle ear
- Usually self-limiting
- Common in children
- Often from … … tract infection
- Secretory form with effusion
- ‘Glue ear’ If … causes a conductive hearing loss
- May need … - grommets (little opening - insert into ear drum - drain)
- Infection or inflammation of middle ear
- Usually self-isolating
- Common in children
- Often from upper respiratory tract infection
- Secretory form with effusion
- ‘Glue ear’ If chronic causes a conductive hearing loss
- May need draining - grommets (little opening - insert into ear drum - drain)
Otosclerosis
- Fusion of staples with oval window
- Maybe why Beethoven went deaf
- Can be fixed by surgery
Otosclerosis
- Fusion of staples with oval window
- Maybe why Beethoven went deaf
- Can be fixed by surgery
The Inner ear
- Cochlea is a long, coiled, … filled tube
- Different parts of tube are tuned to different frequencies
- … end - tuned to high-frequency sound
- … end - tuned to low-frequency sounds
- Cochlea is a long, coiled, fluid filled tube
- Different parts of tube are tuned to different frequencies
- Basal end - tuned to high-frequency sound
- Apical end - tuned to low-frequency sounds
The Inner ear
- Cochlea is a long, …, fluid filled tube
- Different parts of tube are tuned to different frequencies
- Basal end - tuned to …-frequency sound
- Apical end - tuned to …-frequency sounds
- Cochlea is a long, coiled, fluid filled tube
- Different parts of tube are tuned to different frequencies
- Basal end - tuned to high-frequency sound
- Apical end - tuned to low-frequency sounds
Cross section of the cochlear duct
Cross section of the cochlear duct
Composition of the cochlear fluids
- Scala vestibuli and scala tympani contain …, a normal extracellular fluid with high Na+ and low K+
- Scala media contains …, an unusual extracellular fluid rich in K+ and low in Na+ (produced by stria vascularis), and an electrical potential of about +90mV
- Scala vestibuli and scala tympani contain perilymph, a normal extracellular fluid with high Na+ and low K+
- Scala media contains endolymph, an unusual extracellular fluid rich in K+ and low in Na+ (produced by stria vascularis), and an electrical potential of about +90mV
Composition of the cochlear fluids
- Scala vestibuli and scala tympani contain perilymph, a normal extracellular fluid with high ….+ and low ….+
- Scala media contains endolymph, an unusual extracellular fluid rich in …+ and low in …+ (produced by stria vascularis), and an electrical potential of about +90mV
- Scala vestibuli and scala tympani contain perilymph, a normal extracellular fluid with high Na+ and low K+
- Scala media contains endolymph, an unusual extracellular fluid rich in K+ and low in Na+ (produced by stria vascularis), and an electrical potential of about +90mV
The organ of Corti
- Detects the sound induced motions of the basilar membrane
- Contains two types of sensory hair cells, inner hair cells and outer hair cells
- Apical membrane of hair cells is bathed in …
- Basolateral membrane of hair cells is bathed in …
- Inner hair cells are innervated by afferent nerve fibres
- Outer hair cells are mainly innervated by efferent nerve fibres
- Only 15,000 hair cells in each human cochlea, not regenerated after loss
- Detects the sound induced motions of the basilar membrane
- Contains two types of sensory hair cells, inner hair cells and outer hair cells
- Apical membrane of hair cells is bathed in endolymph
- Basolateral membrane of hair cells is bathed in perilymph
- Inner hair cells are innervated by afferent nerve fibres
- Outer hair cells are mainly innervated by efferent nerve fibres
- Only 15,000 hair cells in each human cochlea, not regenerated after loss
The organ of Corti
- Detects the sound induced motions of the basilar membrane
- Contains two types of sensory hair cells, inner hair cells and outer hair cells
- Apical membrane of hair cells is bathed in endolymph
- Basolateral membrane of hair cells is bathed in perilymph
- … hair cells are innervated by afferent nerve fibres
- … hair cells are mainly innervated by efferent nerve fibres
- Only 15,000 hair cells in each human cochlea, not … after loss
- Detects the sound induced motions of the basilar membrane
- Contains two types of sensory hair cells, inner hair cells and outer hair cells
- Apical membrane of hair cells is bathed in endolymph
- Basolateral membrane of hair cells is bathed in perilymph
- Inner hair cells are innervated by afferent nerve fibres
- Outer hair cells are mainly innervated by efferent nerve fibres
- Only 15,000 hair cells in each human cochlea, not regenerated after loss
Inner hair cells are innervated by …. nerve fibres
Outer hair cells are mainly innervated by … nerve fibres
Inner hair cells are innervated by afferent nerve fibres
Outer hair cells are mainly innervated by efferent nerve fibres
Mechanotransduction in hair cells
- Deflection of the hair … opens non-selective cation channels, the mechano-electrical transducer (MET) channels, at the lower end of the tip links, between neighbouring sterocilia (‘hairs’)
- K+, the major cation in endolymph enters and depolarises the hair cell, driven by it’s electro-(chemical) gradient [the electrical gradient is +120 to +140 mV; there is little or no chemical gradient]; Ca2+ also enters and causes adaption
- Voltage gated Ca2+ channels open, Ca2+ triggers vesicle release
- Afferent nerve fibres (Aff NE) are activated
- … hair cells are sensory, … hair cells are sensori-motor cells
- Deflection of the hair bundle opens non-selective cation channels, the mechano-electrical transducer (MET) channels, at the lower end of the tip links, between neighbouring sterocilia (‘hairs’)
- K+, the major cation in endolymph enters and depolarises the hair cell, driven by it’s electro-(chemical) gradient [the electrical gradient is +120 to +140 mV; there is little or no chemical gradient]; Ca2+ also enters and causes adaption
- Voltage gated Ca2+ channels open, Ca2+ triggers vesicle release
- Afferent nerve fibres (Aff NE) are activated
- Inner hair cells are sensory, outer hair cells are sensori-motor cells
Mechanotransduction in hair cells
- Deflection of the hair bundle opens non-selective cation channels, the mechano-electrical transducer (MET) channels, at the lower end of the tip links, between neighbouring sterocilia (‘hairs’)
- …+, the major cation in endolymph enters and depolarises the hair cell, driven by it’s electro-(chemical) gradient [the electrical gradient is +120 to +140 mV; there is little or no chemical gradient]; Ca2+ also enters and causes adaption
- Voltage gated Ca2+ channels …, Ca2+ triggers vesicle release
- … nerve fibres (Aff NE) are activated
- Inner hair cells are sensory, outer hair cells are sensori-motor cells
- Deflection of the hair bundle opens non-selective cation channels, the mechano-electrical transducer (MET) channels, at the lower end of the tip links, between neighbouring sterocilia (‘hairs’)
- K+, the major cation in endolymph enters and depolarises the hair cell, driven by it’s electro-(chemical) gradient [the electrical gradient is +120 to +140 mV; there is little or no chemical gradient]; Ca2+ also enters and causes adaption
- Voltage gated Ca2+ channels open, Ca2+ triggers vesicle release
- Afferent nerve fibres (Aff NE) are activated
- Inner hair cells are sensory, outer hair cells are sensori-motor cells
Electromotility of outer hair cells
- Outer hair cells amplify … membrane motion
- … - shorten: … - lengthen
- Prestin, a modified anion exchanger in the basolateral membrane, is the OHC motor
- Outer hair cells amplify basilar membrane motion
- Depolarise - shorten: hyperpolarise - lengthen
- Prestin, a modified anion exchanger in the basolateral membrane, is the OHC motor