Autonomic Nervous System Flashcards
Autonomic Nervous System:
- Part of the …NS
- Involuntary control:
- Regulates operation of the … organs
- Maintains … environment
- Innervates … muscle, … muscle, …
- 3 divisions:
- Sympathetic
- Parasympathetic
- … (the “little brain”)
- Part of the PNS
- Involuntary control:
- Regulates operation of the internal organs
- Maintains internal environment
- Innervates smooth muscle, cardiac muscle, glands
- 3 divisions:
- Sympathetic
- Parasympathetic
- Enteric (the “little brain”)
Autonomic Nervous System:
- Part of the PNS
- … control:
- Regulates operation of the internal organs
- Maintains internal environment
- Innervates smooth muscle, cardiac muscle, glands
- 3 divisions:
- …
- …
- Enteric (the “little …”)
- Part of the PNS
- Involuntary control:
- Regulates operation of the internal organs
- Maintains internal environment
- Innervates smooth muscle, cardiac muscle, glands
- 3 divisions:
- Sympathetic
- Parasympathetic
- Enteric (the “little brain”)
3 divisions of the ANS
- Sympathetic
- Parasympathetic
- Enteric (the “little brain”)
Autonomic function
- … function:
- Fight or flight response
- Maximises use of metabolic resources
- … function:
- Opposite to … division
- Switched on during resting
- Increases/conserves metabolic resources
- Both divisions work together to maintain the … environment
- Sympathetic function:
- Fight or flight response
- Maximises use of metabolic resources
- Parasympathetic function:
- Opposite to sympathetic division
- Switched on during resting
- Increases/conserves metabolic resources
- Both divisions work together to maintain the internal environment
Autonomic function
- Sympathetic function:
- … or … response
- Maximises use of … resources
- Parasympathetic function:
- Opposite to sympathetic division
- Switched on during …
- Increases/conserves metabolic …
- Both divisions work together to maintain the internal environment
- Sympathetic function:
- Fight or flight response
- Maximises use of metabolic resources
- Parasympathetic function:
- Opposite to sympathetic division
- Switched on during resting
- Increases/conserves metabolic resources
- Both divisions work together to maintain the internal environment
Map of the ANS
- What is para? what is sympathetic?

- Sympathetic system is sandwiched between parasympathetic system

- 2 Parasympathetic components - one in …, one in S2 to S4 region of spinal cord
- 1 sympathetic component - … to …. region of spinal cord
- 2 Parasympathetic components - one in brainstem, one in S2 to S4 region of spinal cord
- 1 sympathetic component - T1 to L2 region of spinal cord
General autonomic circuit
- Axons do not pass directly to the … organs
- They form … pathways
- EXCEPT … supply to adrenal medulla
- Axons do not pass directly to the effector organs
- They form disynaptic pathways
- EXCEPT sympathetic supply to adrenal medulla

General autonomic circuit
- Axons do not pass directly to the effector organs
- They form disynaptic pathways
- EXCEPT sympathetic supply to … …
- Axons do not pass directly to the effector organs
- They form disynaptic pathways
- EXCEPT sympathetic supply to adrenal medulla

Neurotransmission - ANS
- Many of the receptors within the ANS provide targets for drugs
- Within autonomic ganglia:
- … is the main neurotransmitter (Although lots of neuropeptides)
- Binds to nicotinic receptors on postganglionic neurons
- Ionotropic ligand-gated (fast): … opens pore, depolarises neuron
- Many of the receptors within the ANS provide targets for drugs
- Within autonomic ganglia:
- Acetylcholine is the main neurotransmitter (Although lots of neuropeptides)
- Binds to nicotinic receptors on postganglionic neurons
- Ionotropic ligand-gated (fast): Acetylcholine opens pore, depolarises neuron
Neurotransmission - ANS
- Many of the receptors within the ANS provide targets for drugs
- Within … …:
- Acetylcholine is the main neurotransmitter (Although lots of neuropeptides)
- Binds to nicotinic receptors on … neurons
- Ionotropic ligand-gated (fast): Acetylcholine opens pore, … neuron
- Many of the receptors within the ANS provide targets for drugs
- Within autonomic ganglia:
- Acetylcholine is the main neurotransmitter (Although lots of neuropeptides)
- Binds to nicotinic receptors on postganglionic neurons
- Ionotropic ligand-gated (fast): Acetylcholine opens pore, depolarises neuron
Neurotransmission - ANS
- Postganglionic sympathetic neurons:
- … is the main neurotransmitter (except sweat glands use acetylcholine)
- Binds to adrenergic receptors on the effector organ
- … G-protein coupled (slow)
- There are multiple subtypes: a1, a2, B1, B2 and B3
- Postganglionic sympathetic neurons:
- Noradrenaline is the main neurotransmitter (except sweat glands use acetylcholine)
- Binds to adrenergic receptors on the effector organ
- Metabotropic G-protein coupled (slow)
- There are multiple subtypes: a1, a2, B1, B2 and B3

Neurotransmission - ANS
- Postganglionic sympathetic neurons:
- Noradrenaline is the main neurotransmitter (except sweat glands use …)
- Binds to … receptors on the effector organ
- Metabotropic G-protein coupled (…)
- There are multiple subtypes: a1, a2, B1, B2 and B3
- Postganglionic sympathetic neurons:
- Noradrenaline is the main neurotransmitter (except sweat glands use acetylcholine)
- Binds to adrenergic receptors on the effector organ
- Metabotropic G-protein coupled (slow)
- There are multiple subtypes: a1, a2, B1, B2 and B3

- A1 - Blood vessels: a1 antagonists used to treat … (E.g. Prazosin)
- B1 - Heart: B1 antagonists used to treat … (E.g. Atenolol)
- B2 - Bronchus: B2 agonists used to treat … (E.g. Salbutamol)
- A1 - Blood vessels: a1 antagonists used to treat hypertension (E.g. Prazosin)
- B1 - Heart: B1 antagonists used to treat hypertension (E.g. Atenolol)
- B2 - Bronchus: B2 agonists used to treat asthma (E.g. Salbutamol)
Neurotransmission -Within adrenal medulla
- … is also the main neurotransmitter
- Binds to nicotinic receptors on … cells
- Causes release of adrenalin/noradrenalin into circulation
- Direct activation of sympathetic effector organs
- Acetylcholine is also the main neurotransmitter
- Binds to nicotinic receptors on chromaffin cells
- Causes release of adrenalin/noradrenalin into circulation
- Direct activation of sympathetic effector organs
Neurotransmission -Within adrenal medulla
- Acetylcholine is also the main neurotransmitter
- Binds to nicotinic receptors on chromaffin cells
- Causes release of …/… into circulation
- … activation of sympathetic effector organs
- Acetylcholine is also the main neurotransmitter
- Binds to nicotinic receptors on chromaffin cells
- Causes release of adrenalin/noradrenalin into circulation
- Direct activation of sympathetic effector organs
Neurotransmission - ANS - Postganglionic sympathetic neurons
- … is the main neurotransmitter
- Binds to … receptors on the effector organ
- … G-protein coupled (slow)
- Cholinergic-muscarinic antagonist (e.g. Atropine) are used to treat bradycardia, dilate pupils, reduce glandular secretions etc.
- Acetylcholine is the main neurotransmitter
- Binds to muscarinic receptors on the effector organ
- Metabotropic G-protein coupled (slow)
- Cholinergic-muscarinic antagonist (e.g. Atropine) are used to treat bradycardia, dilate pupils, reduce glandular secretions etc.
…-muscarinic … (e.g. Atropine) are used to treat bradycardia, dilate pupils, reduce glandular secretions etc.
Cholinergic-muscarinic antagonist (e.g. Atropine) are used to treat bradycardia, dilate pupils, reduce glandular secretions etc.
Sympathetic system - ANS
- Huge system
- Cardiac muscle - … pacemaker activity + contractile force
- Bronchi of lungs - broncho…
- Sweat glands - sweat …
- Hair follicles - piloerection
- Blood vessels - vaso… of arteries/arterioles
- Abdomino-pelvic viscera - inhibits peristalsis + gastric secretion, stimulate glucagon secretion, stimulates secretion of adrenalin
- Eye - … pupils
- Huge system
- Cardiac muscle - increases pacemaker activity + contractile force
- Bronchi of lungs - bronchodilation
- Sweat glands - sweat secretion
- Hair follicles - piloerection
- Blood vessels - vasoconstriction of arteries/arterioles
- Abdomino-pelvic viscera - inhibits peristalsis + gastric secretion, stimulate glucagon secretion, stimulates secretion of adrenalin
- Eye - dilates pupils
Sympathetic system - ANS
- Huge system
- Cardiac muscle - … pacemaker activity + contractile force
- Bronchi of lungs - bronchodilation
- Sweat glands - sweat …
- Hair follicles - pilo…
- Blood vessels - vasoconstriction of arteries/arterioles
- Abdomino-pelvic viscera - … peristalsis + gastric secretion, … glucagon secretion, … secretion of adrenalin
- Eye - … pupils
- Huge system
- Cardiac muscle - increases pacemaker activity + contractile force
- Bronchi of lungs - bronchodilation
- Sweat glands - sweat secretion
- Hair follicles - piloerection
- Blood vessels - vasoconstriction of arteries/arterioles
- Abdomino-pelvic viscera - inhibits peristalsis + gastric secretion, stimulate glucagon secretion, stimulates secretion of adrenalin
- Eye - dilates pupils
Sympathetic trunk/chain
- Interconnected … ganglia close to bodies of vertebrae
- Extends from cervical to sacral levels
- Preganglionic fibres enter sympathetic trunk through … rami communicantes
- Interconnected paravertebral ganglia close to bodies of vertebrae
- Extends from cervical to sacral levels
- Preganglionic fibres enter sympathetic trunk through white rami communicantes

Preganglionic fibres
- On entering the trunk, preganglionic fibres either:
- Synapse in … - same level or travel to another level OR
- Pass through ganglion into splanchnic nerves to synapse in … ganglia
- On entering the trunk, preganglionic fibres either:
- Synapse in ganglion - same level or travel to another level OR
- Pass through ganglion into splanchnic nerves to synapse in prevertebral ganglia

Preganglionic fibres
- On entering the trunk, preganglionic fibres either:
- … in ganglion - same level or travel to another level OR
- … … ganglion into splanchnic nerves to synapse in prevertebral ganglia
- On entering the trunk, preganglionic fibres either:
- Synapse in ganglion - same level or travel to another level OR
- Pass through ganglion into splanchnic nerves to synapse in prevertebral ganglia

Preganglionic fibres
- On entering the trunk, preganglionic fibres either:
- Synapse in ganglion - same level or travel to another level OR
- Pass through ganglion into splanchnic nerves to synapse in … …
- On entering the trunk, preganglionic fibres either:
- Synapse in ganglion - same level or travel to another level OR
- Pass through ganglion into splanchnic nerves to synapse in prevertebral ganglia

Postganglionic fibres
- Postganglionic neurons much … numerous than preganglionic
- Approx 1: 20 ratio …-to …-ganglionic neurons
- … axons synapse on many … neurons
- Leads to concurrent activation of … neurons
- = mass discharge
- Postganglionic neurons much more numerous than preganglionic
- Approx 1: 20 ratio pre-to post-ganglionic neurons
- Preganglionic axons synapse on many postganglionic neurons
- Leads to concurrent activation of postganglionic neurons
- = mass discharge
From sympathetic trunk, postganglionic fibres follow one of two routes:
- To the … (Sweat glands, hair follicles, blood vessels)
- Via … rami communicans back into spinal nerves
- To the … (heart, lungs, head)
- Via medial branches/plexus
- From prevertebral ganglia, postganglionic fibres form plexus around viscera
- To the periphery (Sweat glands, hair follicles, blood vessels)
- Via grey rami communicans back into spinal nerves
- To the viscera (heart, lungs, head)
- Via medial branches/plexus
- From prevertebral ganglia, postganglionic fibres form plexus around viscera

Cervical sympathetic
- Cervical ganglia supply head, upper limbs and heart
- Three cervical ganglia - …, …, …
- Cervical ganglia supply head, upper limbs and heart
- Three cervical ganglia - superior, middle, inferior

Cervical sympathetic
- Cervical ganglia supply head, upper limbs and heart
- Three cervical ganglia - …, …, …
- Cervical ganglia supply head, upper limbs and heart
- Three cervical ganglia - superior, middle, inferior

Stellate ganglion:
- Fused … cervical and … thoracic ganglia
- Anterior to neck of … rib
- Stellate ganglion block can be used to treat … pain
- Fused inferior cervical and first thoracic ganglia
- Anterior to neck of first rib
- Stellate ganglion block can be used to treat chronic pain

… ganglion block can be used to treat chronic pain
Stellate ganglion block can be used to treat chronic pain
Cervical sympathetic - Postganglionic fibres:
- Exit via grey rami communicantes to spinal nerves to … limbs
- Some “piggyback” down common carotid artery to …
- Exit via grey rami communicantes to spinal nerves to upper limbs
- Some “piggyback” down common carotid artery to heart

Cervical sympathetic - Postganglionic fibres:
- Some “piggy back” up internal/external carotid artery to head
- Internal carotid plexus:
- To eye (… pupil, … eye lid)
- To lacrimal gland (… secretions)
- External carotid plexus:
- To submandibular and parotid glands (… secretions)
- Some “piggy back” up internal/external carotid artery to head
- Internal carotid plexus:
- To eye (dilate pupil, raise eye lid)
- To lacrimal gland (inhibit secretions)
- External carotid plexus:
- To submandibular and parotid glands (inhibits secretions)

Horner’s syndrome
- Due to a disruption of the … supply to the head
- Any part of pathway: hypothalamus to preganglionic neurons
- E.g. lesions within brainstem/cervical spinal cord (in MS) - Affecting descending autonomic regulatory pathways
- Due to a disruption of the sympathetic supply to the head
- Any part of pathway: hypothalamus to preganglionic neurons
- E.g. lesions within brainstem/cervical spinal cord (in MS) - Affecting descending autonomic regulatory pathways
Signs of horner’s syndrome
- Signs include:
- Miosis (Constriction of pupil)
- Ptosis (drooping of eyelid)
- Anhydrosis (lack of sweating)
- Miosis (Constriction of pupil)
- Ptosis (drooping of eyelid)
- Anhydrosis (lack of sweating)
all signs of what syndrome?
horner’s syndrome

Thoracic sympathetic
- Thoracic ganglia supply thorax, heart, lungs and abdominal viscera
- Thoracic ganglia supply thorax, heart, lungs and abdominal viscera

Thoracic sympathetic
- Postganglionic fibres exit via:
- … rami communicantes to spinal nerves
- … branches to heart and lungs
- Postganglionic fibres exit via:
- Grey rami communicantes to spinal nerves
- Medial branches to heart and lungs

Thoracic sympathetic:
- Preganglionic fibres exit via:
- Thoracic … nerves to abdomen
- Greater, lesser, least - to … ganglia
- Preganglionic fibres exit via:
- Thoracic splanchnic nerves to abdomen
- Greater, lesser, least - to prevertebral ganglia

Thoracic splanchnic nerves
- Thoracic splanchnic nerves - pierce … - synapse in prevertebral ganglia
- Postganglionic fibres form prevertebral plexus around viscera
- Innervates abdominal … (including the …)
- Thoracic splanchnic nerves - pierce diaphragm - synapse in prevertebral ganglia
- Postganglionic fibres form prevertebral plexus around viscera
- Innervates abdominal viscera (including the foregut)

- Thoracic splanchnic nerves - pierce diaphragm - synapse in prevertebral ganglia
- Postganglionic fibres form prevertebral plexus around viscera
- Innervates abdominal … (including the …)
- Thoracic splanchnic nerves - pierce diaphragm - synapse in prevertebral ganglia
- Postganglionic fibres form prevertebral plexus around viscera
- Innervates abdominal viscera (including the foregut)
Lumbar sympathetic
- Lumbar ganglia supply the abdominal … and … limb
- Postganglionic fibres exit via:
- … rami communicantes to spinal nerves:
- Preganglionic fibres exit via:
- Lumbar … nerves to abdomen - (synapse in prevertebral ganglia)
- Lumbar ganglia supply the abdominal viscera and lower limb
- Postganglionic fibres exit via:
- Grey rami communicantes to spinal nerves:
- Preganglionic fibres exit via:
- Lumbar splanchnic nerves to abdomen - (synapse in prevertebral ganglia)

Sacral sympathetic
- Sacral ganglia supply … and … limb
- Postganglionic fibres exit via:
- … rami communicantes to spinal nerves (lower limb)
- Sacral … nerves to pelvic organs
- NOTE: other sympathetic splanchnic nerves mainly contain preganglionic fibres
- Sacral ganglia supply pelvis and lower limb
- Postganglionic fibres exit via:
- Grey rami communicantes to spinal nerves (lower limb)
- Sacral splanchnic nerves to pelvic organs
- NOTE: other sympathetic splanchnic nerves mainly contain preganglionic fibres

Parasympathetic system
- Smaller division:
- Cardiac muscle - … pacemaker activity + contractile force
- Bronchi of lungs - broncho…
- Sweat glands - …
- Hair follicles - …
- Blood vessels - none (Except … erectile tissue)
- Abdomino-pelvic viscera - … peristalsis + gastric secretions
- Eye - … pupils
- Salivary + lacrimal glands - … of watery saliva and tears
- Smaller division:
- Cardiac muscle - decreases pacemaker activity + contractile force
- Bronchi of lungs - bronchoconstriction
- Sweat glands - none
- Hair follicles - none
- Blood vessels - none (Except male erectile tissue)
- Abdomino-pelvic viscera - stimulates peristalsis + gastric secretions
- Eye - constricts pupils
- Salivary + lacrimal glands - secretion of watery saliva and tears
Parasympathetic system
- Smaller division:
- … muscle - decreases pacemaker activity + contractile force
- Bronchi of lungs - bronchoconstriction
- … glands - none
- … follicles - none
- …. vessels - none (Except male erectile tissue)
- Abdomino-pelvic viscera - stimulates peristalsis + gastric secretions
- Eye - constricts pupils
- Salivary + lacrimal glands - … of watery saliva and tears
- Smaller division:
- Cardiac muscle - decreases pacemaker activity + contractile force
- Bronchi of lungs - bronchoconstriction
- Sweat glands - none
- Hair follicles - none
- Blood vessels - none (Except male erectile tissue)
- Abdomino-pelvic viscera - stimulates peristalsis + gastric secretions
- Eye - constricts pupils
- Salivary + lacrimal glands - secretion of watery saliva and tears
Parasympathetic preganglionic fibres
- Preganglionic neurons within:
- …
- … matter spinal cord (part that forms S2-S4 spinal nerves)
- All ganglia located close to target organ:
- Preganglionic neurons within:
- Brainstem
- Grey matter spinal cord (part that forms S2-S4 spinal nerves)
- All ganglia located close to target organ:

Parasympathetic preganglionic fibres
- Preganglionic neurons within:
- Brainstem
- Grey matter spinal cord (part that forms ..-.. spinal nerves)
- All ganglia located close to … organ:
- Preganglionic neurons within:
- Brainstem
- Grey matter spinal cord (part that forms S2-S4 spinal nerves)
- All ganglia located close to target organ:

Cranial parasympathetic
- Cranial preganglionic neuronal cell bodies are within … … nuclei
- Cranial preganglionic neuronal cell bodies are within cranial nerve nuclei

Only cranial nerves with a parasympathetic component - 4
Only cranial nerves with a parasympathetic component - CN III, VII, IX, X

Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming …-… nucleus (CN III)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming edinger-westphal nucleus (CN III)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming … … nucleus (CN VII)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming superior salivatory nucleus (CN VII)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming … … nucleus (CN IX)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming inferior salivatory nucleus (CN IX)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming nucleus ambigious, dorsal motor nucleus (CN …)
Cranial nerve preganglionic neuronal cell bodies within cranial nerves - forming nucleus ambigious, dorsal motor nucleus (CN X)
What 4 cranial nerves have a parasympathetic component?

Preganglionic axons pass through cranial nerves to ganglia

… nerve passes to heart, lungs and abdominal viscera
Vagus nerve passes to heart, lungs and abdominal viscera

Sacral parasympathetic function
- Bladder (urination)
- Contraction of bladder wall
- … to bladder sphincter
- Rectum (Defecation)
- … of rectal sphincter
- Sexual function
- … in erectile tissues
- Bladder (urination)
- Contraction of bladder wall
- Inhibition to bladder sphincter
- Rectum (Defecation)
- Inhibition of rectal sphincter
- Sexual function
- Vasodilation in erectile tissues
Sacral parasympathetic function
- Bladder (urination)
- … of bladder wall
- Inhibition to bladder sphincter
- Rectum (Defecation)
- Inhibition of rectal …
- Sexual function
- Vasodilation in … tissues
- Bladder (urination)
- Contraction of bladder wall
- Inhibition to bladder sphincter
- Rectum (Defecation)
- Inhibition of rectal sphincter
- Sexual function
- Vasodilation in erectile tissues
In men - … component causes vasodilation in erectile tissue - erection, whereas … tissue causes ejaculation
In men - parasympathetic component causes vasodilation in erectile tissue - erection, whereas sympathetic tissue causes ejaculation
Enteric nervous system
- In walls of gastrointestinal tract
- Two very complicated plexi:
- … - regulates muscle contraction (also known as myenteric plexus)
- … - regulates glandular secretions (also known as submucosal plexus)
- Contains 10-100 billion neurons
- Very … - retains functions after all central connections severed
- Truly autonomic
- In walls of gastrointestinal tract
- Two very complicated plexi:
- Auerbach’s - regulates muscle contraction (also known as myenteric plexus)
- Meissner’s - regulates glandular secretions (also known as submucosal plexus)
- Contains 10-100 billion neurons
- Very unusual - retains functions after all central connections severed
- Truly autonomic

Enteric nervous system
- In walls of gastrointestinal tract
- Two very complicated plexi:
- Auerbach’s - regulates … contraction (also known as … plexus)
- Meissner’s - regulates … secretions (also known as … plexus)
- Contains 10-100 billion neurons
- Very unusual - retains functions after all central connections severed
- Truly …
- In walls of gastrointestinal tract
- Two very complicated plexi:
- Auerbach’s - regulates muscle contraction (also known as myenteric plexus)
- Meissner’s - regulates glandular secretions (also known as submucosal plexus)
- Contains 10-100 billion neurons
- Very unusual - retains functions after all central connections severed
- Truly autonomic

Enteric nervous system

Central control - ANS
