Retroperitoneum - Part 4 Flashcards
What is Addison disease caused by?
By partial or complete failure of adrenocortical function
- hypofunction
What gets destroyed with Addison disease?
Adrenal cortex
What do you lose with Addison disease?
Loss of cortisol and aldosterone secretions
How is Addison disease diagnosed?
Diagnosis is established if the amount of cortisol in the plasma and steroid in the urine do not increase after stimulation with ACTH
What is the cause of Addison disease? (5)
- Autoimmune reaction 2. Tuberculosis
- Adrenal hemorrhage 4. Chronic infection
- Surgical removal of both adrenal glands
What are the clinical findings for Addison disease? (9)
- Anorexia
- Bronze skin pigmentation
- Chronic fatigue
- Dehydration
- Emotional changes
- GI disorders
- Hypotension
- Weakness
- Salt cravings
What gets elevated with Addison disease?
Serum potassium
What decreases with Addison disease? (2)
- Serum sodium
2. Glucose
Is Addison disease more common in males or females?
Females
Adrenogenital syndrome
Congenital disorder causing excessive secretion of sexual hormones and adrenal androgens
What are the causes of Adrenogenital syndrome? (2)
- Adrenal tumor
2. Hyperplasia
What are the clinical findings of Adrenogenital syndrome? (4)
- Increases in body hair
- Deepening of the voice
- Atrophy of the uterus
- Acne
What is increased with Adrenogenital syndrome?
Androgen production
Conn syndrome
Excessive production of aldosterone
What causes Conn syndrome? (2)
- Adrenal hyperplasia
- male prevalence - Adrenal carcinoma
- rare