Biliary System - Part 6 Flashcards
What is the 5th most common malignancy?
GB carcinoma
What are the risk factors for GB carcinoma? (5)
- Cholelithiasis
- Porcelain GB
- Cholecystitis
- Female prevalence
- Greater than 60 years of age
What are the clinical findings for GB carcinoma? (8)
- Asymptomatic
- RUQ pain
- Palpable mass
- Jaundice
- Anorexia
- Nausea/vomiting
- Elevated alkaline
phosphatase - Mild increase in AST and ALT levels
What is the US appearance for GB carcinoma? (6)
- Thick, irregular GB wall
- Irregular intraluminal mass
- Immobile mass
- Cholelithiasis
- 90% of cases - Lymphadenopathy
- Metastatic liver lesions
What are 5 differential diagnosis for GB carcinoma?
- Adenoma
- Sludge
- Cholecystitis
- Adenomyomatosis
- Metastases
Is GB carcinoma more common in male or females?
Females
What are the direct extensions of metastatic GB disease? (3)
- Pancreas
- Stomach
- Bile duct
What are the indirect extensions of metastatic GB disease? (4)
- Melanoma
- most common - Lung
- Kidney
- Esophagus
What are the clinical findings for metastatic GB disease? (5)
- Asymptomatic
- RUQ pain
- Jaundice
- Nausea/vomiting
- Elevated alkaline
phosphatase
What is the US appearance for metastatic GB disease? (3)
- Focal GB wall thickening
- Irregular intraluminal mass
- Non-shadowing
- Absence of gallstones
What are 3 differetial diagnosis for metastatic GB disease?
- Cholecystitis
- Adenoma
- Primary carcinoma
What are the complications of acute cholecystitis? (5)
- Ascending cholangitis
- Empyema
- Perforation
- Pericholecystic
or liver abscess - Septicemia
What are the causes of acute cholecystitis? (3)
- Obstruction of the cystic duct
- Infection
- Idiopathic
What are the risk factors of acute cholecystitis? (3)
- Female prevalence
- Cholelithiasis
- 40-50 years of age
Is acute cholecystitis more common in male or females?
Females
What are the clinical findings of acute cholecystitis? (7)
- Severe epigastric or RUQ pain
- Biliary colic
- Positive Murphy sign 4. Nausea/vomiting
- Fever and chills
- Elevated AST, bilirubin, and alkaline phosphatase
- Leukocytosis
What is the US appearance of acute cholecystitis? (7)
- Thick, edematous GB wall
- “halo sign” - Impacted stone in the cystic duct or GB neck
- Cholelithiasis
- 90% of cases - Pericholecystic fluid
- Positive Murphy sign
- Peripheral hyperemia on colour
Doppler - Sludge
What are 3 differential diagnosis for acute cholecystitis?
- Liver abscess
- Ascites
- Non-fasting patient
What are causes of emphysematous cholecystitis? (2)
- Cholelithiasis
2. Idiopathic
What are the clinical findings of emphysematous cholecystitis? (4)
- RUQ pain
- Nausea/vomiting
- Fever
- Leukocytosis
What is the US appearance of emphysematous cholecystitis? (4)
- Echogenic focus(i) within the GB wall or lumen
- Ill-defined posterior acoustic shadowing
- Cholelithiasis
- Pericholecystic fluid
What are 4 differential diagnosis of emphysematous cholecystitis?
- Acute cholecystitis
- Porcelain GB
- Large gallstone
- Intestinal air
What are the risk factors for gangrenous cholecystitis? (3)
- Diabetes
- Older adult
- Male prevalence
What are the clinical findings for gangrenous cholecystitis? (5)
- RUQ pain radiating to the back
- Positive Murphy sign
- Fever
- Leukocytosis
- Elevated AST, bilirubin, and
alkaline phosphatase
What is the US appearance for gangrenous cholecystitis? (4)
- Diffuse echogenic focus within the lumen
- Immobile
- Non-shadowing
- Non-layering
What are 4 differential diagnosis for gangrenous cholecystitis?
- Acute cholecystitis
- Emphysematous cholecystitis
- Adenoma
- Carcinoma
Is gangrenous cholecystitis more common in males or females?
Males
What are the risk factors for GB perforation? (5)
- Diabetes
- Older adult
- Infection
- Cholelithiasis
- Trauma
What are the clinical findings for GB perforation? (5)
- RUQ mass
- Severe RUQ or epigastric pain
- Positive Murphy sign 4. Nausea/vomiting
- Leukocytosis
What is the US appearance for GB perforation? (3)
- Edematous, thick GB wall
2. Pericholecystic fluid 3. Cholelithiasis
What is the 3 differential diagnosis for GB perforation?
- Ascites
- Hepatic
abscess - Perforated peptic ulcer