III - A. Virology | 26. Slow viral diseases Flashcards
I. Basics
1. What are Slow Viruses?
Slow Viruses= virus or virus-like agent that after latency, follows a slow, progressive course spanning months to years frequently involving CNS
I. Basics
2. What are the 4 features of slow infections?
II. Conventional slow infection
1. What are the features of Conventional slow infection?
II. Conventional slow infection
2. What are the 4 viruses cause conventional slow infections?
II. Conventional slow infection
3. What are the features of HIV?
HIV – slow infection in CNS – AIDS demetia
II. Conventional slow infection
4. What are the features of Morbilli virus (measles)?
Morbilli virus (measles) – Subacute sclerotising panencephalitis (SSPE) in some cases, years after the acute infection
II. Conventional slow infection
5. What are the features of Rubela virus?
Rubela virus – Progressive rubella panencephalitis (PRP)
II. Conventional slow infection
6. What are the features of JC virus?
JC virus
- Progressive multifocal leukoencephalopathy (PML) in inimmunosupressed
III. Non-conventional slow infections
1. What are the features of Non-conventional slow infections?
caused by other agents eg. prions
III. Non-conventional slow infections
2. What are the features of prion?
III. Non-conventional slow infections
3. What is the disease caused by prion?
- Misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein
→ Amyloid plaques are formed in the CNS – neurodegeneration - Vacuolas in neurons, astrocyte proliferaton, fusion of neurons with glia
- Spongiform encephalitis – brain tissue becomes spongy
III. Non-conventional slow infections
4. How does prion spread?
III. Non-conventional slow infections
5. What are symptoms, diagnosis and treatment of Non-conventional slow infections?
- Sy: memory impairment, progressive dementia, personality changes, difficulties with movement
- D: imaging of CNS eg. MRI, EEG, detection of proteins from CSF
- Treatment: not available, fatal outcome
III. Non-conventional slow infections
6. What are the examples of Non-conventional slow infections?