III - A. Virology | 26. Slow viral diseases Flashcards

1
Q

I. Basics
1. What are Slow Viruses?

A

Slow Viruses= virus or virus-like agent that after latency, follows a slow, progressive course spanning months to years frequently involving CNS

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2
Q

I. Basics
2. What are the 4 features of slow infections?

A
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3
Q

II. Conventional slow infection
1. What are the features of Conventional slow infection?

A
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4
Q

II. Conventional slow infection
2. What are the 4 viruses cause conventional slow infections?

A
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5
Q

II. Conventional slow infection
3. What are the features of HIV?

A

HIV – slow infection in CNS – AIDS demetia

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6
Q

II. Conventional slow infection
4. What are the features of Morbilli virus (measles)?

A

Morbilli virus (measles) – Subacute sclerotising panencephalitis (SSPE) in some cases, years after the acute infection

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7
Q

II. Conventional slow infection
5. What are the features of Rubela virus?

A

Rubela virus – Progressive rubella panencephalitis (PRP)

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8
Q

II. Conventional slow infection
6. What are the features of JC virus?

A

JC virus
- Progressive multifocal leukoencephalopathy (PML) in inimmunosupressed

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9
Q

III. Non-conventional slow infections
1. What are the features of Non-conventional slow infections?

A

caused by other agents eg. prions

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10
Q

III. Non-conventional slow infections
2. What are the features of prion?

A
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11
Q

III. Non-conventional slow infections
3. What is the disease caused by prion?

A
  • Misfolded proteins with the ability to transmit their misfolded shape onto normal variants of the same protein
    → Amyloid plaques are formed in the CNS – neurodegeneration
  • Vacuolas in neurons, astrocyte proliferaton, fusion of neurons with glia
  • Spongiform encephalitis – brain tissue becomes spongy
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12
Q

III. Non-conventional slow infections
4. How does prion spread?

A
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13
Q

III. Non-conventional slow infections
5. What are symptoms, diagnosis and treatment of Non-conventional slow infections?

A
  • Sy: memory impairment, progressive dementia, personality changes, difficulties with movement
  • D: imaging of CNS eg. MRI, EEG, detection of proteins from CSF
  • Treatment: not available, fatal outcome
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14
Q

III. Non-conventional slow infections
6. What are the examples of Non-conventional slow infections?

A
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