III - A. Virology | 17. Rhabdoviruses Flashcards

1
Q

I. Nervous system infections
1. What are the viruses that can infect nervous system?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

I. Nervous system infections
2. What are the RNA viruses that infect nervous system?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

II. Rhabdoviruses - lyssa virus (rabies)
1. What is the genetic material of Rhabdoviruses?

A

linear ssRNA genome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

II. Rhabdoviruses - lyssa virus (rabies)
1. What are the features of Lyssa virus?

A
  • infects warm blooded animals
  • only replicates in nervous tissue
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

II. Rhabdoviruses - lyssa virus (rabies)
2. What is the source of infection of lyssa virus (rabies)?

A
  • infected animal
  • infected person
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

II. Rhabdoviruses - lyssa virus (rabies)
3. What is the route of transmission of lyssa virus (rabies)?

A
  • through bite of the infected animal / person
  • through transplantation (cornea)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

II. Rhabdoviruses - lyssa virus (rabies)
4. What is the pathomechanism of lyssa virus (rabies)?

A
  • viral replication at the original site of the infection
  • enters peripherial nerves, migrates into the CNS
  • CNS infection
  • reaches the cornea, kidneys, salivary glands through axons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

II. Rhabdoviruses - lyssa virus (rabies)
5. What are signs and symptoms of lyssa virus (rabies)?

A
  • incubation period (2-16 weeks))
    ___
  • nausea, vomiting, fever
  • itching, burning sensation at bite site
  • muscle spasm (pharynx – hydrophobia!)
  • paralysis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

II. Rhabdoviruses - lyssa virus (rabies)
6. What is the diagnosis of lyssa virus (rabies)?

A
  1. virus detection from different tissues
    - immunfluoreszcencia
  2. observation of the infection source (animal)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

II. Rhabdoviruses - lyssa virus (rabies)
7. What is the therapy for lyssa virus (rabies)?

A

post-exposition prophylactic vaccination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

II. Rhabdoviruses - lyssa virus (rabies)
8. How do we prevent lyssa virus (rabies)?

A
  • vaccination of wild animals (lyssa-glycoprotein embedded in
    food)
  • vaccination of dogs (attenuated virus)
  • vaccination of people in certain professions (inactivated virus)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly