III - A. Virology | 21. Bunyaviruses

Question 1

I. Bunyaviruses in general
1. What are the genetic material and morphology of Bunyaviruses?

Answer 1

• Ss neg RNA viruses, segmented genome – rapid recombination
• Obtains envelope from Golgi body complex of host cells
• 3 circular segments
• Arbor viruses (except hantavirus)
• Enveloped, helical
  (- mostly causing viral haemorrhagic fevers)

Question 2

I. Bunyaviruses in general
2. What are the genus belong to bunyaviruses?

Answer 2

here

Question 3

I. Bunyaviruses in general
3. What are the viruses belong to Hantaviridae genus?

Answer 3

Hantaan virus

Question 4

I. Bunyaviruses in general
4. What are the viruses belong to Plebovirus genus?

Answer 4

• Rift valley fever virus
• Naples, Sicilian, Toscana virus

Question 5

I. Bunyaviruses in general
5. What are the viruses belong to Orthobunyavirus genus?

Answer 5

California encephalitis virus, La Crosse virus

Question 6

I. Bunyaviruses in general
6. How do Bunyaviruses spread?

Answer 6

Spread: vectors or rodents – robovirus: rodent borne

Question 7

I. Bunyaviruses in general
7. What are the 2 prominent viruses belong to Bunyaviruses?

Answer 7

Hanta-, Crimean-Congo haemorrhagic fever virus

Question 8

II. Hantavirus
1. How does Hantavirus spread?

Answer 8

Spread: zoonotic, from rodents with bite or bodily fluids

Question 9

II. Hantavirus
2. What are the 2 diseases caused by Hantavirus?

Answer 9

• Hantavirus pulmory syndrome - New World hantaviruses
• Haemorrhagic fever with renal syndrome – Old world hantaviruses

Question 10

II. Hantavirus
2A. What are the features of Hantavirus pulmory syndrome?

Answer 10

Hantavirus pulmory syndrome - New World hantaviruses
- on American continent, caused by Sin Nombre virus (SNV)
- reservoir: deer mice flu-like symptoms followed by sudden dyspnea, lung oedema, high mortality

Question 11

II. Hantavirus
2B. What are the features of Haemorrhagic fever with renal syndrome?

Answer 11

Question 12

III. Crimean-Congo hemorrhagic fever virus (CCHF)
1. How does CCHF spread?

Answer 12

• Spread: tick bite (Hyalomma), animals, human to human
• Mostly among people working with animals

Question 13

III. Crimean-Congo hemorrhagic fever virus (CCHF)
2. What are the symptoms of CCHF?

Answer 13

• Fever, vomiting, stiff neck, hepatomegaly, bleeding into skin, mucosa, viscera
• Shock, high mortality (30-40%)

Question 14

III. Crimean-Congo hemorrhagic fever virus (CCHF)
3. What are the diagnosis and treatment of CCHF?

Answer 14

D: PCR, serology
Th: supportive, ribavirin?