III - A. Virology | 16. Paramyxoviruses (Mumps and Morbillivirus) Flashcards
I. Basics
1. What are the 4 viruses belong Paramyxoviridae?
- measles virus
- parainfluenza virus
- mumps virus
- RSV virus
I. Basics
2. What are the genetic material and morphology of Paramyxoviridae?
1/ - ssRNA genome
2/ helical capsid
3/ enveloped virus
II. measles virus
1. Which genus does measles virus belong?
Morbillivirus
II. Measles virus
2. What is the feature of Measles virus?
Surface protein: neuraminidase (NA)
II. Measles virus
3. What is the source of infection of measles virus?
Infected individual
II. Measles virus
4. What is the route of transmission of measles virus?
through respiratory droplets
II. Measles virus
5. What is the pathomechanism?
- infects respiratory epithelial cells
- infects RES cells (liver, spleen) through 1st viraemia
- infects skin epithelium and neurons through 2nd viraemia
- rash is due to the immunreaction against infected epithelial cells
- the virus has an immunosuppressive effect
II. Measles virus
6. What are the disease, signs and symptoms of measles virus?
- highly contagious!
- 7-13 days of incubation
- fever, coughing, conjunctivitis
- photophobia
- Koplik spots (small buccal ulcers)
- rash
II. Measles virus
7. What are complications of measles virus?
- postinfection encephalitis (autoimmune disease, 7-10 days after disease onset)
- pneumonia
- SSPE (7 years after the acute infection, personality changes, blindness, memory issues, seizures)
II. Measles virus
8. What is the diagnosis for Measles virus?
- based on signs and symptoms
- respiratory sample - PCR, antigen detection
II. Measles virus
9. How do we preven Measles virus?
MMR vaccine
III. Mumps
1. What is the source of infection of mumps virus?
Infected individual
III. Mumps
2. What is the route of transmission of mumps virus?
Through respiratory droplets
III. Mumps
3. What is the pathomechanism of mumps virus?
- infects the epithelial cells of the respiratory tract
- infects the ductal cells of salivary glans through viraemia
III. Mumps
4. What are disease, signs and symptoms of mumps virus?
- 10-14 days of incubation
- flu like symptoms
- painful and symmetric inflammation of salivary glands