IIA. Systemic Bacteriology | 8. Klebsiella, Enterobacter, Serratia. Flashcards

1
Q

I. Klebsiella genus
1. What are the general features of Klebsiella genus?

A
  1. Gram negative rod
  2. Ubiquitous
  3. Normal intestinal flora (Enterobacteriaceae)
  4. Polysaccharide capsule
  5. Non-motile
  6. Lactose fermenter
  7. Facultative anaerobe
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2
Q

I. Klebsiella genus
2. Give examples of Klebsiella genus

A

K. pneumoniae
K. oxytoca
K. granulomatis
K. rhinoscleromatis
K. ozaenae

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3
Q

I. Klebsiella genus
3. What are biochemical properties of Klebsiella genus?

A
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4
Q

I. Klebsiella genus
4. Describe Pathogenesis & clinical features of Klebsiella genus

A
  1. Facultative pathogens
  2. Lobar pneumonia (Friedländer pneumonia) → K. pneumoniae
  3. Urinary tract infections
  4. Sinusitis, Otitis media, Cholecystitis, Cholangitis
  5. Wound infections, Sepsis
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5
Q

I. Klebsiella genus
5A. What is the diagnosis for Klebsiella genus?

A
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6
Q

I. Klebsiella genus
5B. How should we use culture for the diagnosis of Klebsiella genus?

A
  1. Simple agar: mucoid colonies with urine smell
  2. EMB agar: purple colonies
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7
Q

I. Klebsiella genus
5C. How should we use Biochemical tests for the diagnosis of Klebsiella genus?

A

glucose, lactose, urease + / indole, –

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8
Q

I. Klebsiella genus
5D. How should we use serology for the diagnosis of Klebsiella genus?

A

capsule swelling test

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9
Q

I. Klebsiella genus
6. What is the treatment for Klebsiella genus?

A
  • Multidrug resistant
  • ESBL
  • MBL
  • Antibiotic susceptibility test
  • Carbapenems, Monobactams, Fluoroquinolones, Aminoglycosides
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10
Q

I. Klebsiella genus
7. what are the features of Klebsiella pneumonia?

A
  1. Member of the normal intestinal flora
  2. Diseases:
    ● lobar pneumonia
    ● UTI, sinusitis, otitis
    ● Wound infection
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11
Q

I. Klebsiella genus
8. What is the feature of Klebsiella oxytoca?

A

iatrogenic
(relating to illness caused by medical examination or treatment.)

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12
Q

I. Klebsiella genus
8. What is the feature of Klebsiella oxytoca?

A

iatrogenic
(relating to illness caused by medical examination or treatment.)

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13
Q

I. Klebsiella genus
9. What is the feature of Klebsiella ozaenae?

A

Infection of mucous membrane in nasal cavity cavity

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14
Q

II. Enterobacteriaceae Family
1. What are the main features of Enterobacteriaceae Family?

A

● Naturally appearance: soil, water, vegetation and animals GI
● Morphology: 2-4 m rod
● Gram-negative
● Oxidase -negative
Either normal flora or cause pathogenesis
MOTILE

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15
Q

II. Enterobacteriaceae Family
2. What are the Two main types of infectious disease are associated with Enterobacteriaceae?

A

● intestinal diseases
● extraintestinal diseases

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16
Q

II. Enterobacteriaceae Family
3. How do we cultivate Enterobacteriaceae?

A

● non fastidious bacteria
● on selective medium (identification)

17
Q

II. Enterobacteriaceae Family
4. How do we test Enterobacteriaceae Family?

A

● Sugar fermentation test
● Protein metabolism test

18
Q

II. Enterobacteriaceae Family
5. What are the features of Enterobacteriaceae Nosocomial infections?

A
19
Q

II. Enterobacteriaceae Family
6. What is the treatment for Enterobacteriaceae?

A

● β-lactam + enzyme inhibitor combination
● 3rd gen. cephalosporins
● carbapenems
● aminoglycosides
● fluoroquinolones

20
Q

III. Serratia Marcescens
1. What are the main features of Serratia Marcescens?

A
  • Urease and catalase positive
  • Slow lactose fermenter
  • opportunistic pathogen
  • nosocomial infections
  • sepsis, UTI
  • Produces a red pigment
  • MOTILE