I-C. Protozoology | 28. Leishmania Flashcards
I. Leishmania
1. What are the features of Leishmania?
- causative agent of leishmaniasis
- present in Central- and South America, North-Africa, Middle-East
I. Leishmania
2A. What are 3 species of Leishmania? What do they cause?
3 different species
- L. donovani => Visceral leishmaniasis (kala-azar)
- L. tropica => cutan leishmaniasis
- L. brasiliensis => mucocutan leishmaniasis
I. Leishmania
3. What is the route of infection by Leishmania?
By the bite of sandfly
- animal reservoir!
I. Leishmania
4. What is pathomechanism of Leishmania
- promastigotes enter during sandfly bite
- turn into amastigote form, infect RES cells
- proliferate intracellulary, kill infected cells
- amastigotes reenter sandfly during bite
I. Leishmania
5. What are the sign of symptoms of visceral leishmaniasis?
- fever, fatigue, weight loss
- hepatosplenomegaly, bone marrow infection
- death
(L. donovani)
I. Leishmania
5B. What are the reservoir and vector of Visceral leishmaniasis?
- Vector: phlebotomus fly
I. Leishmania
6A. What are the sign of symptoms of cutan leishmaniasis?
- ulcerating papule at the site of bite
- heals slowly
- can spread directly
I. Leishmania
6B. What are the reservoir and vector of cutan leishmaniasis?
- Reservoir: rodents, dogs
- Vector: Phlebotomus fly
I. Leishmania
7. What are the sign of symptoms of mucocutan leishmaniasis?
- ulcerating papule at the site of bite
- mucosal surfaces (nose, mouth) is involved
I. Leishmania
7B. What are the reservoir and vector of mucocutan leishmaniasis?
- Reservoir: rodents, dogs
- Vector: phlebotomus fly
I. Leishmania
8. What is the diagnosis of Leishmania
amastigote detection from biopsy by microscopy or PCR
I. Leishmania
9. What is the therapy of Leishmania
- antimony + IFN gamma
- amphotericin B + pentamidin in visceral leishmaniasis
