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AA Microbio Semifinal > III - A. Virology | 11. Herpesviruses (EBV, CMV, HHV6, HHV7, HHV8) > Flashcards

III - A. Virology | 11. Herpesviruses (EBV, CMV, HHV6, HHV7, HHV8) Flashcards

1
Q

I. Basics
1. List beta-herpesviruses and gamma-herpesviruses

A
  • betaherpesviruses: CMV, HHV6, HHV7
  • gammaherpesviruses: EBV, HHV8
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2
Q

II. CMV and EBV
1. What are the genetic material and morphology of CMV and EBV?

A
  • dsDNA genome
  • icosahedral capsid
  • enveloped viruses
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3
Q

II. CMV & EBV - CMV
2A. What are the features of Cytomegalovirus (CMV, HHV5)

A
  • leads to cytopathic effects in infected cells
  • infected cells do not lyse, viral production is continous
  • inflammation and tissue damage in affected organs
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4
Q

II. CMV & EBV - CMV
2B. What is the source of infection of Cytomegalovirus (CMV, HHV5)

A

nfected individual (latency!)

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5
Q

II. CMV & EBV - CMV
2C. What is the route of transmission of Cytomegalovirus (CMV, HHV5)

A
  • saliva, genital mucous, blood, breast milk
  • transplacentar transmission!
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6
Q

II. CMV & EBV - CMV
2D. What is the pathomechanism of Cytomegalovirus (CMV, HHV5)

A

Infects exocrine glands, renal tubules, monocytes and endothelial cells

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7
Q

II. CMV & EBV - CMV
2E. What are the diseases caused by Cytomegalovirus (CMV, HHV5)?

A
  • often asymptomatic in healthy individuals
  • can cause mononucleosis
  • pneumonitis, chorioretinitis, encephalitis in immunosuppressed
  • congenital / perinatal infection may lead to mental retardation, periventricular calcification, chorioretinitis, deafness, pneumonitis, hepatitis
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8
Q

II. CMV & EBV - CMV
2F. What are the diagnosis for Cytomegalovirus (CMV, HHV5)?

A

blood sample
- serology (detection of IgM)
- PCR

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9
Q

II. CMV & EBV - CMV
2G. What are the therapy and prevention for Cytomegalovirus (CMV, HHV5)?

A
  • gancyclovir, cidofovir, foscarnet
  • screning of donated organs and blood (serological status)
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10
Q

II. CMV & EBV - EBV
3A. What are the features of Ebstein-Barr virus (EBV, HHV4)?

A
  • causes cytopathic effects in infected cells
  • may transform infected cells (leads to cancer)
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11
Q

II. CMV & EBV - EBV
3B. What is the source of infection of Ebstein-Barr virus (EBV, HHV4)?

A

Infected individual (latency!)

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12
Q

II. CMV & EBV - EBV
3C. What is the ROUTE of infection of Ebstein-Barr virus (EBV, HHV4)?

A

mainly througH saliva (continous virus production even during latency!)

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13
Q

II. CMV & EBV - EBV
3D. What is the pathomechanism of Ebstein-Barr virus (EBV, HHV4)?

A
  • infects mucous membranes and CD21 positive B-lymphocytes
  • viral proteins may lead to the immortalisation of B-cells
    (may lead to cancer!)
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14
Q

II. CMV & EBV - EBV
3E. What are the diseases caused by Ebstein-Barr virus (EBV, HHV4)?

A
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15
Q

II. CMV & EBV - EBV
3F. What re the features of mononucleosis infectiosa (glandular fever) caused by EBV?

A
  • the virus replicates in the oropharynx and parotid gland
  • 30-50 days long incubation period, then fever, sore throat, splenomegaly, lymphocytosis
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16
Q

II. CMV & EBV - EBV
3G. What is the diagnosis of EBV?

A
  1. based on clinical signs and symptoms
  2. serological tests may be useful
    - Paul-Bunnel reaaction (+ plasma agglutinates sheep RBCs)
    - detection of viral proteins with ELISA (EBNA, VCA)
17
Q

II. CMV & EBV - EBV
3H. What is the therapy for EBV?

18
Q

II. CMV & EBV - EBV
3I. What is „accidental diagnosis” by EBV?

A

in acute EBV infection the administration of beta-lactam antibiotics (especially aminopenicillins) may lead to a generalised rash
=> „ampicillin rash”

19
Q

III. HHV6, HHV7 and HHV8
1. What are the genetic material and morphology of HHV6 & HHV7

A
  • dsDNA genome
  • icosahedral capsid
  • enveloped viruses
21
Q

III. HHV6, HHV7 and HHV8 - HH6
2A. What are the features of HH6?

A

It has two distinct subtypes (HHV6A, HHV6B)

21
Q

III. HHV6, HHV7 and HHV8 - HH6
2B. What is the source of infection of HH6?

A

infected individual

22
Q

III. HHV6, HHV7 and HHV8 - HH6
2C. What is the route of transmission of HH6?

A

probably through saliva

23
Q

III. HHV6, HHV7 and HHV8 - HH6
2D. What is the pathomechanism of HH6?

A

infects T-cells

24
Q

III. HHV6, HHV7 and HHV8 - HH6
2E. What is the disease caused by HH6?

A
  • HHV6B leads to roseola infantum in children
  • HHV6A does not cause an acute infection, but in immunosuppressed patients it can reactivate from its latency and lead to encephalitis, chorioretinitis, pneumonitis
25
Q

III. HHV6, HHV7 and HHV8 - HH7
3A. What are the features of HH7?

A
  • quite similar to HHV6
  • majority of the population older then 3 years old is seropositive after
26
Q

III. HHV6, HHV7 and HHV8 - HH7
3B. What is the source of infection of HH7?

A

infected individual

27
Q

III. HHV6, HHV7 and HHV8 - HH7
3C. What is the route of transmission of HH7?

A

probably through saliva

28
Q

III. HHV6, HHV7 and HHV8 - HH7
3D. What is the pathomechamism of HH7?

A

infects T-cells

29
Q

III. HHV6, HHV7 and HHV8 - HH7
3E. What is the disease caused by HH7?

A

roseola infantum

30
Q

III. HHV6, HHV7 and HHV8 - HHV8
4A. What are the features of HHV8?

A
  • Kaposi’s sarcoma vírus (KHSV)
  • leads to transsformation (leads to cancer)
  • primary infection is often asymptomatic
31
Q

III. HHV6, HHV7 and HHV8 - HHV8
4B. What is the source of infection of HHV8?

A

infected individual

32
Q

III. HHV6, HHV7 and HHV8 - HHV8
4C. What is the route of transmission of HHV8?

A
  • Through direct contact
  • sexually transmitted
33
Q

III. HHV6, HHV7 and HHV8 - HHV8
4D. What is of pathomechanism of HHV8?

A

probably infects B-lymphocytes and other cells

34
Q

III. HHV6, HHV7 and HHV8 - HHV8
4E. What are the diseases caused by HHV8?

A

Kaposi’ sarcoma (vessel proliferation)
=> INDEX disease!

35
Q

III. HHV6, HHV7 and HHV8 - HHV8
4F. What are the diagnosis for HHV8?

A
  • serology
  • PCR

AA Microbio Semifinal (99 decks)

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