III - A. Virology | 13. Picorna and Caliciviruses Flashcards
I. Picornaviruses
1. What are the features of Picornaviruses? (include genetic material and morphology)
- Name: Pico-RNA: „small RNA viruses”
- Non-enveloped viruses: resistance to environmental conditions
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I. Picornaviruses
2. How do Picornaviruses spread?
from the environment, mostly feco-orally
I. Picornaviruses
3A. What are the most important picornaviruses?
I. Picornaviruses
3B. What are the most important Picornaviruses of enterovirus genus?
- Poliovirus
- Coxsackie A & B viruses
- Rhinoviruses
I. Picornaviruses
3C. What are the most important Picornaviruses of hepatovirus genus?
- Hepatitis A virus
I. Picornaviruses - poliovirus
4A. What are the features of poliovirus?
- Belongs to Enterovirus genus
- Does not cause enteric disease!!
I. Picornaviruses - poliovirus
4B. How does poliovirus spread?
- Sheds and spread from the enteric system with stool – fecooral infection
- Resistant to environmental factors and acids
- Poor hygiene/sanitation enhances the spread
I. Picornaviruses - poliovirus
4C. What are the symptoms of poliovirus?
- Most of the infections are asymptomatic
- Can lead to severe central nervous system infection with paralysis and death
- Eradicated from most of world via vaccination
I. Picornaviruses - poliovirus
4D. What is the Clinical presentation of poliovirus?
I. Picornaviruses - poliovirus
4E1. What are the diseases caused by poliovirus?
POLIOMYELITIS – PARALYTIC POLIO
I. Picornaviruses - poliovirus
4E2. What are the features of poliomyelitis - paralytic polio?
I. Picornaviruses - poliovirus
4E3. what is Post-polio syndrome?
progressive muscle weakness in polio survivors decades later
I. Picornaviruses - poliovirus
4F. How do we prevent disease caused by poliovirus (poliomyelitis)?
I. Picornaviruses - poliovirus
4G. What is the diagnosis for disease caused by poliovirus (poliomyelitis)?
PCR from CSF
I. Picornaviruses - poliovirus
4i. What is the treatment for disease caused by poliovirus (poliomyelitis)?
- No antiviral therapy
- Ventilation, physiotherapy, surgery for contractures
I. Picornaviruses - rhinovirus
5A. What are the features of rhinovirus?
- Name: „Rhinos”: nose in Greek
- More than 100 serotypes – we can get infected that many times
- Very frequent infections
I. Picornaviruses - rhinovirus
5B. How does rhinovirus spread?
Spread: respiratory droplets, contaminated hands
I. Picornaviruses - rhinovirus
5C1. What is the clinical representation of rhinovirus?
Clinical representation: RHINITIS / COMMON COLD
- Nasal discharge, nasal obstruction, sneezing, coughing
- Self-limiting infection, last ~ 1 week
- Tx: no specific treatment; analgesics, decongestants
I. Picornaviruses - rhinovirus
5C2. What is the treatment for rhinovirus?
no specific treatment; analgesics, decongestants
I. Picornaviruses - Coxsackie A and B viruses
6A. What are the features of Coxsackie A and B viruses?
Worldwide distribution, mostly affecting children
I. Picornaviruses - Coxsackie A and B viruses
6B. How does Coxsackie A and B viruses spread?
respiratory droplets and feco-oral route
I. Picornaviruses - Coxsackie A
6C1. What are the 3 diseases caused by Coxsackie A?
- HERPANGINA
- CONJUNCTIVITIS
- HAND, FOOT, AND MOUTH DISEASE
I. Picornaviruses - Coxsackie A
6C2. What are the symptoms and treatment for HERPANGINA caused by Coxsackie A?
- Mostly affects children
- Sy: High fever, sore throat, herpes-like oral vesicules
- Tx: self-limiting, analgestics
I. Picornaviruses - Coxsackie A
6C3. What is CONJUNCTIVITIS?
Acute hemorrhagic eye infection, pain, swollen eyelids
I. Picornaviruses - Coxsackie A
6C4. What are the symptoms and treatment for HAND, FOOT, AND MOUTH DISEASE caused by Coxsackie A?
I. Picornaviruses - Coxsackie B
7A. What are the 2 diseases caused by Coxsackie B?
- Pleurodynia
- Myocarditis
I. Picornaviruses - Coxsackie B
7B. What are the features, symptoms and treatment for
I. Picornaviruses - Coxsackie B
7B. What are the features, symptoms and treatment for Pleurodynia caused by Coxsackie B?
I. Picornaviruses - Coxsackie B
7C. What are the features, symptoms and treatment for myocarditis caused by Coxsackie B?
I. Picornaviruses
8. Make a summary of diseases caused by COXSACKIE A AND B VIRUSES?
II. caliciviruses
1. What are the genetic material and morphology of caliciviruses?
RNA viruses, no envelope - resistant
II. caliciviruses
2. How does caliciviruses spread?
II. caliciviruses
3. What is the clinical presentation of caliciviruses?
II. caliciviruses
4. What is the diagnosis for caliciviruses?
- based on symptoms
- rarely PCR from stool
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5. What is the treatment for caliciviruses?
replacement of lost fluids
=> IV infusion if needed
III. Extra
1. Make a summary of enteric viruses
Picornaviruses and caliciviruses
III. Extra
2. What is Diagnostics of viral infections?
PCR and/or serology
III. Extra
3. What is Treatment of viral infections?
Usually nothing available
- Except eg. HIV, hepatitis B, C, herpesvirus, influenza
III. Extra
4. What is prevention of viral infections?
Vaccination !