Vasculitides

Question 1

Giant Cell Arteritis

Answer 1

Elderly females

Unilateral headache and jaw claudication

Ass w/ polymyalgia rheumatica

Granulomas

Question 2

Takayasu Arteritis

Answer 2

Asian females < 40 yo

“pulseless disease” b/c weak upper extremity pulses

Granulomas in proximal great vessels

Question 3

Polyarteritis Nodosa

Answer 3

Renal and visceral arteries (GI) but spares lungs

Transmural fibrinoid necrosis

Question 4

Kawasaki

Answer 4

Asian kids < 4 yo

Connjunctuval injection, rash (polymorphus –> desquamating), cervical lymph, strawberry tongue, hand/foot changes

Give aspirin (only time for kids)

Worst comp = coronary artery aneurysm

Question 5

Buerger Disease

Answer 5

Intermittent claudication and gangrene in smokers

Segmental

Smoking cessation prevents progression

Question 6

Granulomatosis w/ Polyangitis

Answer 6

AKA Wegener

Upper resp/ nasal & lower resp & renal

Granulomas in lung

c - ANCA

Question 7

Microscopic Polyangitis

Answer 7

Lung, kidney, skin (palpable purpura)

p-ANCA

NO granulomas and NO nasopharyngeal involvement

Question 8

Churg-Strauss

Answer 8

AKA eosinophilic granulomatosis w/ polyangitis

Asthma, sinusitis, purpura, wrist drop, and GRANULOMAS

Inc IgE

p-ANCA

Question 9

Henoch - Schonlein

Answer 9

Most common childhood systemic vasculitis

Often after URI

Triad - palpable purpura on butt + arthralgias + ab pain

IMMUNE COMPLEX MEDIATED