Basic Pathology Principles Flashcards
Steps of Extravasation
1- Margination and Rolling
- E selectin, P selectin and Glycam1 on vessels
- Sialyl Lewis bodies and L selectin on leuks
2- Tight binding / adhesion
- ICAM and VCAM on vessels
- integrins on leuks
3 - Diapedesis (travel b/n endo cells)
-PECAM1
4- Migration
PDGF
platelet derived growth factor
- vascular remodeling and fibroblast growth collagen synthesis
- released from fibroblasts and platelets
FGF
Fibroblast Growth Factor
angiogenesis
EGF
endodermal growth factor
cell growth via TK (EGFR and Erb)
TGF- beta
angiogenesis and fibrosis
MMPs
tissue remodeling
VEGF
angiogenesis
What diseases cause granulomas?
Tb, leprosy, bartonella henslae, listeria, tertiary syphilis
endemic mycosis - histo
Schistosomiasis
Chronic granulomatous disease
Auto- inflamm - sarcoidosis, Chrons, PBC, subacute thyroiditis, Wegeners, Churg-Straus, temporal arteritis, Takayasu arteritis
Foreign material - talcosis, beryllioisis, hypersensitivity pneumonitis
What inc ESR? (6)
Anemias
Infections
Inflammation
Cancer (mets, multiple myeloma)
Renal Disease
Pregnancy
What dec ESR? (5)
Sickle cell anemia (altered shape)
Polycythemia (inc RBCs dilute aggregation factors)
HF
Microcytosis
Hypo-fibrinogen
What cancers typically produce psammoma bodies?
PSMM
P - papillary carcinoma of thyroid
S - serous cystadenoma of ovary
M - meningioma
M - malignant mesothelioma
Which carcinomas spread by heme? (against norm)
Renal cell carcinoma
Choriocarcinoma
HCC
Follicular thryoid carcinoma
