Renal Tubular Acidosis Flashcards
1
Q
Type 1
A
Distal renal tubule
Defect in ability of alpha intercalated cells to secrete H+
Inc risk of calcium phosphate stones in the basic urine
Hypokalemia because acidosis
Causes - amphotercin b toxicity, analgesic nephropathy, congenital anomalies
2
Q
Type 2
A
Proximal tubule
Defect in bicarbonate reabsorption so inc bicarbonate excretion
Hypokalemia due to acidosis
Causes- fanconi, carbonic anhydrase inhibitors
3
Q
Type 4
A
“Hyperkalemic”
Hypoaldosteronism leading to less K+ secretion - so less NH3 synthesis in proximal tubule and thus less NH4 excretion
Causes - dec aldosterone production (diabetic hyporeninism, ACE inhibitors, ARBs, NSAIDs, heparin, cyclosporine, adrenal insufficiency) or aldosterone resistance (k sparing diuretics, obstruction, TMP/SMX)
