Derm Vocab Flashcards
Hyperkeratosis
Inc thickness of stratum corneum
Ex) psoriasis
Parakeratosis
Hyperkeratosis but retention of nuclei in stratum corneum
Hypergranulosis
Inc thickness of stratum granulosum
Ex) lichen planus
Spongiosis
Epidermal accumulation of edematous fluid in intracellular space
Acantholysis
Separation of epidermal cells
Ex) pemphigus vulgaris
Acanthosis
Epidermal hyperplasia - inc spinosum
Ex) acanthosis nigrans
Skin Layers
Epidermis, Dermis, SubQ
Epidermis broken into …
- Stratum Corneum (keratin)
- Stratum Lucidum
- Stratum Granulosum
- Stratum Spinosum (desmosomes)
- Stratum Basale (stem cells)
“Californians Like Girls in String Bikinis”
Tight Junction
Prevent paracellular movement
Occludens and claudins
Adherens Junction
Keep adjacent cells tethered to ea other
E-cadherin binds adjacent actin filaments via Ca++
Desmosome
structural support via intermediate filaments
Target of pemphigus vulgaris
Gap Junction
Connexons for electrical and chemical communication
Hemi-desmosomes
Connect keratin in basal cell to underlying BM
Integrins bind collagen and laminin in BM
Target of bullous pemphigoid
