Monoclonal Antibody Drugs

Question 1

Alemtuzumab

Answer 1

CD52

CLL, MS

Question 2

Bevacizumab

Answer 2

VEGF

Colorectal cancer, RCC, non small cell lung cancer

Question 3

Cetuximab

Answer 3

EGFR

Colorectal and head/neck cancer

Question 4

Rituximab

Answer 4

CD20 (B cells)

B cell NHL, CLL, RA, ITP

Question 5

Trastuzumab

Answer 5

HER2/neu

Breast and gastric cancers

Question 6

Adalimumab, certolizumab, golimumab, infliximab

Answer 6

Soluble TNF-alpha

IBD, RA, ankylosing sphondylitis, psoriasis

Question 7

Daclizumab

Answer 7

CD25 (part of IL-2 receptor)

Relapsing MS

Question 8

Eculizumab

Answer 8

C5 complement protein

Paroxysmal nocturnal hemoglobinuria

Question 9

Natalizumab

Answer 9

alpha4 - integrin (WBC adhesion molecule)

MS, Chrons

Question 10

Ustekinumab

Answer 10

IL-12 and IL-23

Psoriasis and psoriatic arthritis

Question 11

Abciximab

Answer 11

IIb/IIIa

Anti-platelet for cath lab

Question 12

Denosumab

Answer 12

RANK ligand (on osteoclasts)

Osteoporosis

Question 13

Omalizumab

Answer 13

IgE

Refractory asthma (prevent IgE from binding Fcepsilon- RI)

Question 14

Palivizumab

Answer 14

RSV F protein

RSV prophylaxis in at risk infants

“VI for virus”

Question 15

Ranibizumab

Answer 15

VEGF

Neovascular age-related macular degeneration, proliferative diabetic retinopathy and macular edema