Neuro Drugs

Question 1

-barbital OR thiopental

Answer 1

Barbiturates

Inc GABA A duration by binding allosteric site

Question 2

-epam, -olam OR chlordiazepoxide

Answer 2

Benzos

Inc GABA A frequency by binding allosteric site

Question 3

Non - benzo Hypnotics (3)

Answer 3

Zolpidem, Zaleplon, esZopiclone

Act on BZ1 subtype of GABA receptor

Question 4

Suvorexant

Answer 4

orexin receptor antagonist for insomnia

Question 5

Ramelteon

Answer 5

Melatonin receptor agonist - binds MT1 and MT2 in suprachiasmatic nucleus

Question 6

Triptans

Answer 6

5-HT 1B/1D agonists

Causes vasoconstriction, prevents vasoactive peptide release and inhibits trigeminal nerve activation

SEROTONIN SYNDROME

Question 7

Dopamine Agonists for Parkinson’s

Answer 7

Bromocriptine (ergot derivative - less preferred)

Pramipexole

Ropinirole

Question 8

Amantadine

Answer 8

Inc dopamine release and dec dopamine reuptake

Question 9

Entacapone / Tolcapone

Answer 9

Put a cap on COMT

Inhibit COMT to prevent breakdown of L-dopa –> 3-OMD in periphery

Tolcapone can also block COMT in central nervous system (dopamine –> 3-methoxytyramine)

Question 10

Selegiline

Answer 10

Blocks MAO- B (CNS) so blocks dopamine –> DOPAC

Question 11

What do you give to lessen the cholinergic side effects of Parkinson’s drugs?

Answer 11

Benztropine and trihexyphenidyl (anti-muscarinics)