Tumor Immunohistochemistry Flashcards
1
Q
Keratin
A
-Epithelial cells (carcinoma)
2
Q
Vimentin
A
-Intermediate filament in connective tissue cells (mesenchyme)
3
Q
Desmin
A
-Muscle cells
4
Q
GFAP
A
-Neuroglial cells (astrocytes, Schwann cells, oligodendrocytes)
5
Q
Neurofilament
A
-Neurons (like neuroblastoma)
6
Q
PSA
A
-Prostate epithelium
7
Q
Thyroglobulin
A
-Thyroid follicular cells
8
Q
ER
A
- Estrogen Receptor
- Breast epithelium
9
Q
Chromogranin
A
-Neuroendocrine cells (small cell carcinoma of lung and carcinoid tumors)
10
Q
S-100
A
-Melanoma, Schwannoma, Langerhans cell histiocytes
11
Q
Alkaline Phosphatase
A
- Mets to bone or liver or Paget of bone
- Placental ALP in seminoma
MUST EXCLUDE HEPATIC ORIGIN
12
Q
AFP
A
HCC
Hepatoblastoma
Yolk sac tumor or mixed testicular tumor
13
Q
Beta - HCG
A
Hydatiform mole, choriocarcinoma or mixed germ cell
14
Q
CA 19-9
A
Pancreatic adenocarcinoma
15
Q
CA 125
A
Ovarian cancer
