Anti-Parasites Flashcards

1
Q

Pyrimethamine

A

Toxo (pyramids)

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2
Q

Suramin and Melarsoprol

A

Trypanosoma brucei (suramin for serum and melarsprol for CNS like melatonin)

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3
Q

Nifurtimox

A

Trypanosoma cruzi (fur boots)

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4
Q

Sodium Stibogluconate

A

Leishmania (give T bone steak to desert zombie)

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5
Q

Permethrin

A

MAO: neuronal membrane depolarization via Na+ channels

Scabies and lice

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6
Q

Malathion

A

MAO: acetylcholinesterase inhibitor

Scabies and lice

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7
Q

Lindane

A

MAO: blocks GABA channels

Neurotoxicity

Scabies and lice

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8
Q

Chloroquine

A

MAO: blocks detoxification of heme into hemozoin –> heme accumulates and is toxic to plasmodium

Resistance: membrane pump

Often resistant so use others

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9
Q

Other Malaria Drugs

A

Artemether/lumefantrine

Atovaquone/ proguanil

Quinidine in US (cinchoism)

Quinine in other parts of world

Artesunate

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10
Q

Mebendazole

A

MAO: microtubule inhibitor for helminths

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11
Q

Other Helminth Drugs

A

Pyrantel pamoate (PAM)

Ivermectin

Diethylcarbamazine (diet and carb magazine)

Praziquantel (pretzels)

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