Anti-Parasites Flashcards
Pyrimethamine
Toxo (pyramids)
Suramin and Melarsoprol
Trypanosoma brucei (suramin for serum and melarsprol for CNS like melatonin)
Nifurtimox
Trypanosoma cruzi (fur boots)
Sodium Stibogluconate
Leishmania (give T bone steak to desert zombie)
Permethrin
MAO: neuronal membrane depolarization via Na+ channels
Scabies and lice
Malathion
MAO: acetylcholinesterase inhibitor
Scabies and lice
Lindane
MAO: blocks GABA channels
Neurotoxicity
Scabies and lice
Chloroquine
MAO: blocks detoxification of heme into hemozoin –> heme accumulates and is toxic to plasmodium
Resistance: membrane pump
Often resistant so use others
Other Malaria Drugs
Artemether/lumefantrine
Atovaquone/ proguanil
Quinidine in US (cinchoism)
Quinine in other parts of world
Artesunate
Mebendazole
MAO: microtubule inhibitor for helminths
Other Helminth Drugs
Pyrantel pamoate (PAM)
Ivermectin
Diethylcarbamazine (diet and carb magazine)
Praziquantel (pretzels)