Hormone Signaling

Question 1

Which hormones use cAMP? (13)

Answer 1

Basophils - FSH, LH, ACTH, TSH

ADH (at V2 receptors)

Melatonin stimulating hormone (same as ACTH)

PTH and calcitonin

H2 histamine receptors (Gs)

GHRH, CRH

hCG and glucagon

Question 2

Which hormones use cGMP?

Answer 2

Think vasodilators

NO, BNP, ANP, EDRF (endo derived relaxing factor)

Question 3

Which hormones use IP3?

Answer 3

GnRH and TRH

H1 histamine receptors (Gq)

Oxytocin and ADH (at V1 receptors) both posterior pituitary

Angio II

Gastrin

Question 4

Which hormones work intracellularly? What motif do their receptors have in common?

Answer 4

Progesterone, estrogen, testosterone

T3/T4

Aldosterone and cortisol

Vit D

**Intracellular receptors contain a zinc finger for DIRECT DNA binding

Question 5

Which hormones use receptor tyrosine kinases?

Answer 5

Insulin

GROWTH FACTORS - IGF-1, FGF, PDGF, EGF

Question 6

Which hormones use non-receptor tyrosine kinases?

Answer 6

Epo, thrombopoietin

Prolactin and GH (acidophiles)

G-CSF

Immunomodulators (cytokines like IL-2, IL-6 and IFN)