Bone Tumors Flashcards
1
Q
Osteochondroma
A
Benign
Males < 25 yo
Bony exostosis budding off main bone w/ cartilage cap
2
Q
Giant Cell Tumor
A
Benign
20-40 yo
Epiphysis of long bones (tips)
Soap bubble on imaging and multinucleated giants cells w/ RANKL
3
Q
Osteosarcoma
A
Malignant
Biomodal - 10to20 yo and >65 yo
Metaphysis
Sunburst on imaging
4
Q
What are risk factors for osteosarcoma? (4)
A
Paget
Bone infarcts
Familial retinoblastoma
Li-Fraumeni syndrome (germline p53 mutation)
5
Q
Ewing Sarcome
A
Malignant
Boys < 15 yo
Diaphysis (long shaft) or pelvis, scapula, ribs
Anaplastic small blue cells - AGGRESSIVE but responsive to chemo
Onion skin periosteal reaction in bone
6
Q
What is the genetic defect associated w/ Ewing sarcoma?
A
t(11;22)
Causes EWS-FLI fusion protein
11 + 22 = 33 (Patrick Ewing’s jersey number)
