Paraneoplastic Syndromes Flashcards
Acanthosis Nigricans
Hyper-pigmented velvet plaques in axilla and neck
Gastric adenocarcinoma
Sign of Leser-Trelat
Sudden onset of multiple seborrheic keratoses
GI adeno and other visceral malignancies
Hypercalcemia
PTHrP
Squamous cell carcinoma of lung, head, neck
Renal, bladder, breast and ovarian carcinoma
Inc calcitrol
Lymphoma
Cushing
Inc ACTH
Small cell lung cancer
SIADH
Inc ADH
Small cell lung cancer
Polycythemia
Inc Epo
Renal cell carcinoma, HCC, hemangioblastoma, pheo, leiomyoma
Pure Red Cell Aplasia
anemia w/ low reticulocytes
thymoma
Good Syndrome
Hypogammaglobulin
thymoma
Trousseau Syndrome
Migratory superficial thrombophlebitis
adenocarcinoma (esp pancreas)
Marantaric Endocarditis
Bland on valves
adenocarcinoma (esp pancreas)
Anti - NMDA receptor Encephalitis
Psych, memory deficits, sz, dyskinesias, autonomic instability, language dysfunction
Ovarian teratoma
Opsoclonus - Myoclonus Ataxia Syndrome
“dancing eyes dancing feet”
Neuroblastoma (kids), small cell lung cancer (adults)
Paraneoplastic cerebellar degeneration
Antibodies against antigens in Purkinje cells
Small cell lung cancer, breast cancers, Hodgkin lymphoma
Paraneoplastic encephalomyelitis
Antibodies against Hu antigens in neurons
Small cell lung cancer
Lambert-Eaton Myasthenic Syndrome
Antibodies against pre-synaptic Ca channels at NMJ
Small cell lung cancer
