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Step 1 Memorization Hour > Leukemia And Lymphoma Genetics/Biomarkers > Flashcards

Leukemia And Lymphoma Genetics/Biomarkers Flashcards

1
Q

Burkitt Lymphoma

A

8;14 translocation so c-Myc increased by Ig heavy chain

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2
Q

CML

A

BCR-ABL hybrid

Also known as the Philadelphia chromosome

Seen in ALL as well but less common and poor prognosis if present

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3
Q

Mantle Cell Lymphoma

A

11;14 translocation

Cyclin D1 amplified by Ig heavy chain

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4
Q

Follicular Lymphoma

A

14;18 translocation

Bcl2 amplification by Ig heavy chain (apoptosis inhibitor)

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5
Q

APL

A

Acute promyelocytic leukemia

15;17 translocation

Use all trans retinoic acid

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6
Q

AML

A

Myeloperoxidase positive

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7
Q

Hairy Cell Leukemia

A

TRAP positive

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8
Q

ALL

A

Tdt+ and CD10+

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9
Q

CLL

A

CD20 CD23 and CD5 positive even though B cells

Smudge cells on peripheral smear

Richter transformation to Lymphoma

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Step 1 Memorization Hour (127 decks)

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