Skin Cancers Flashcards
1
Q
Basal Cell Carcinoma
A
MOST COMMON
Sun-exposed spots, pearly, telangiectaias, rolled borders
Pallisading nuclei
2
Q
Squamous Cell Carcinoma
A
SECOND MOST COMMON
Sunlight, immunosuppression, arsenic
Ulcerative red lesions w/ scale (can be on lips)
Keratin pearls on histo
3
Q
What is the precursor of squamous cell carcinoma?
A
Actinic keratosis - scaly plaque
4
Q
Melanoma
A
Most risk of mets
Sun-exposure, dysplastic nevi, fair skin
ABCDEs - asymmetry, borders, color variation, diameter (> 6 mm), evolution
5
Q
What are the genetics and tumor marker of melanoma?
A
S-100 tumor marker
BRAF mutation - so use vemurafenib (BRAF kinase inhibitor)
6
Q
What is the #1 prognostic factor in melanoma?
A
Depth of tumor (Breslow thickness)
