MEN Syndromes Flashcards

1
Q

MEN1

A

3 P’s

Parathyroid adenoma

Pancreas endocrine tumors (gastrinoma, insulinoma, VIPoma, glucagonoma)

Pituitary adenoma

Mutation = menin tumor suppressor (chromosome 11)

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2
Q

MEN 2A

A

2 P’s

Parathyroid hyperplasia

Pheo

+ Medullary thyroid carcinoma (calcitonin)

Mutation = RET (tyrosine kinase) in neural crest cells

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3
Q

MEN2B

A

1 P

Pheo

+ Medullary thyroid carcinoma

+ neuromas anywhere in oral / GI

Mutation = RET

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