MEN Syndromes Flashcards
1
Q
MEN1
A
3 P’s
Parathyroid adenoma
Pancreas endocrine tumors (gastrinoma, insulinoma, VIPoma, glucagonoma)
Pituitary adenoma
Mutation = menin tumor suppressor (chromosome 11)
2
Q
MEN 2A
A
2 P’s
Parathyroid hyperplasia
Pheo
+ Medullary thyroid carcinoma (calcitonin)
Mutation = RET (tyrosine kinase) in neural crest cells
3
Q
MEN2B
A
1 P
Pheo
+ Medullary thyroid carcinoma
+ neuromas anywhere in oral / GI
Mutation = RET