General Virus Characteristics

Question 1

DNA Viruses in General

Answer 1

• all dbl stranded except parvovirus (parvo = small)
• all linear except Papilloma, Polyoma and hePadnavirus (circular)
• replicate in nucleus except pox (carries own DNA-dep RNA polymerase)
• all icosahedral capsid exept pox (complex)

HHAPPPPy - herpes, hepadna, adeno, pox, parvo, papillo, polyoma

Question 2

RNA Viruses in General

Answer 2

• all sngl strand except Reo (“repeat - O” dbl)

- all replicate in cytoplasm except influenza and retroviruses

Question 3

Pos Stranded RNA Viruses (7)

Answer 3

Retro

Toga

Flavivirus

Coronavirus

Hepevirus

Calcivirus

Picornavirus

**rest are neg sense

Question 4

Which viruses are naked? (8)

Answer 4

PAPP - papillo, parvo, adeno, polyoma (DNA)

CPR - calci, picorno, reo (RNA)

Hippie - Hepevirus

“PAPP and CPR on a hippie”

Question 5

Segmented Viruses

Answer 5

all RNA - all capable of antigenic shift

BOAR - bunya, orthomixo, arena, reo

Question 6

6 Use Receptors (name receptors too)

Answer 6

EBV - CD21

CMV - integrins (heparin sulfate)

HIV - CXCR4 , CD4, CCR5

Parovirus B19 - P antigen on RBCs

Rabies - nicotinic Ach receptors

Rhinovirus - ICAM (on endothelial cells)

Question 7

Live Attenuated Vaccines (7)

Answer 7

MMR

Yellow Fever

Rotavirus

Influenza (intranasal)

VZV

Small pox

Sabin polio virus

Question 8

Killed Vaccines (4)

Answer 8

Rabies

Influenza (injected)

(salk) Polio

HAV

ONLY HUMORAL

RIP Salk + Hep A

Question 9

Subunit Vaccines (2)

Answer 9

HBV and HPV (6, 11, 16, 18)