Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step 1 Memorization Hour > Immunosuppression Drugs > Flashcards

Immunosuppression Drugs Flashcards

1
Q

Cyclosporine

A

Calcineurin inhibitor that binds cyclophilin

Prevents IL-2 transcription

NEPHROTOXIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Tacrolimus

A

Calcineurin inhibitor that binds FK506

Prevents IL-2 transcription

NEPHROTOXIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sirolimus

A

AKA rapamycin

Inhibits mTOR to block IL-2 response

NOT nephrotoxic but causes pancytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Basiliximab

A

Monoclonal antibody against IL-2 receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Azathioprine

A

AZA –> 6MP which blocks PRPP amidotransferase for purine synthesis

Degraded by xanthinine oxidase so inc toxicity if on allopurinol for gout

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mycophenolate mofetil

A

Reversible inhibition of IMP DH in purine synthesis

Pancytopenia, inc risk invasive CMV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Corticosteroids

A

Inhibit NF-kB which dec transcription of many cytokines (dec B and T cell function)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Step 1 Memorization Hour (127 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions