Cytokines Flashcards
1
Q
IL-1
A
- Fever (“hot” of hot T-bone stEAK)
- Acute inflammation
- Activates endothelium to express adhesion molecules
- Chemokine secretion
2
Q
IL-2
A
- Stimulates T cells (“T” of hot T-bone stEAK)
- Stimulates growth of helper, cytotoxic and regulatory T cells
- Also stimulates growth of NK cells
3
Q
IL-3
A
- Stimulates bone marrow (“bone” of hot T-bone stEAK)
- Supports growth and differentiation of bone marrow stem cells
4
Q
IL-4
A
- Stimulates IgE production (“E” in of hot T-bone stEAK)
- Induces differentiation of T cells into Th2 cells
- Promotes growth of B cells and enhances IgE and IgG class switching
5
Q
IL-5
A
- Stimulates IgA production (“A” in of hot T-bone stEAK)
- Promotes growth and differentiation of B cells
- Enhances class switching to IgA
- Stimulates growth and differentiation of eosinophils
6
Q
IL-6
A
- Stimulates aKute phase reactants (“K” of hot T-bone stEAK)
- Also causes fever
7
Q
IL-8
A
- Chemotactic factor for neutrophils
- “clean up on aisle 8” to get neutrophils to area to CLEAR infection
8
Q
IL-10
A
- Attenuates inflammatory response (atTENuate)
- Dec expression of MHC class II and Th1 cytokines
- Inhibits macrophages and dendritic cells
9
Q
IL-12
A
- Induced differentiation of T cells into Th1 cells
- Activate NK cells
10
Q
TNF- alpha
A
- Cachexia
- Maintains Tb granulomas
- Activates endothelium / EBC recruitment and leak
- Can mediate sepsis
- Secreted by macrophages
11
Q
TGF- beta
A
-also attenuates inflammatory response
12
Q
Interferon-gamma
A
- Secreted by NK cells or T cells in response to antigen or IL-12
- Activates NK cells to kill virus-infected cells
- Activates macrophages to kill phagocytosed pathogens
- TH1 REACTION so inhibits Th2 differentiation
“Interferons interfere w/ viruses”
