Anti-Depressants

Question 1

SSRIs (6)

Answer 1

Fluoxetine, fluvoxamine

Peroxitene, Setraline

Escitalopram, citalopram

Question 2

SNRIs (5)

Answer 2

Venlafaxine (social anxiety, panic, PTSD, OCD)

Desvenlafaxine

Duloxetine (dual - NE and serotonin)

Levomilnacipran, milnacipran

Question 3

Tricyclics

Answer 3

Amitriptyline, nortriptyline (ami is tertiary and has more anti-cholinergic effects)

Imipramine, desipramine, clomipramine

Doxepin, amoxapine

**Also inhibit serotonin and NE reuptake

Question 4

MAOIs

Answer 4

Tranylcypromine

Phenelizine

Isocarboxazid

Selegiline (MAO-B specific - Parkinson’s)

Question 5

Buproprion

Answer 5

Inhibits NE and dopamine reuptake

Also used for smoking cessation

Stimulant side effects

Good if sexual dysfunction on SSRI

Question 6

Mirtazapine

Answer 6

Alpha-2 antagonist - inc NE and serotonin release

BUT potent 5-HT2 and 5-HT3 antagonist + H1 antagonist

Sedating, inc appetite / wt gain, dry mouth

Question 7

Trazadone

Answer 7

ZZZ - more for insomnia or depressed patients w/ insomnia

Blocks 5-HT2, alpha 1 and H1

Priapism (trazaBONE)

Question 8

Varenicline

Answer 8

Nicotinic Ach partial agonist

Also used in smoking cessation

Sleep disturbance

Question 9

Vilazodone

Answer 9

Inhibits serotonin reuptake AND 5-HT1a partial agonist

MDD and GAD

May cause serotonin syndrome if used w/ others

Question 10

Vortioxetine

Answer 10

Inhibits serotonin reuptake AND 5-HT1a partial agonist and 5-HT3 antagonist

MDD only

May cause serotonin syndrome if used w/ others