4/28/17 Tumor immunology Flashcards
What type of macrophages have secretion of IFN gamma and TNF alpha and leads to anti-tumor inflammatory environment?
-M1
What type of macrophages or myeloid derived suppressor cells can actually promote tumor growth by inhibiting appropriate immune responses?
-M2
How does cellular immunity kill tumor cells?
-CD8 T cells recognize the antigen on the target cell
How do granzymes enter the tumor cell?
-Via perforin holes
When there is a connection of FasL and Fas what occurs to the cell?
-Apoptosis
What are four types of tumor antigens?
- Mutate self protein
- Product of oncogene or mutated tumor suppressor gene
- Overexpressed or aberrantly expressed self protein
- Oncogenic virus
What are different ways tumor vaccines have been developed?
- Dendritic cells transfected with plasmid expressing tumor antigen
- Vaccinate with tumor-antigen presenting dendritic cell
- Dendritic cells pulsed with tumor antigens
T/F Most cancer vaccines to date have been prophylactic rather than therapeutic
False
-They have been therapeutic rather than prophylactic
What is the antibody approach to kill tumor cells?
- Block the CTLA4 and PD1 response to keep the T cells going
- Block the CD20 to eliminate transformed B cells
What are the three E’s of cancer immunoediting?
- Elimination
- Equilibrium
- Escape
What is one of the first things to happen during the elimination phase?
-Produce IFN-Gamma
What does IFN-gamma do for cancer elimination?
-Tells some tumor cells to die by anti-proliferative and apoptotoic mechanisms
What happens during the second part of the elimination phase?
-Tumor cell debri’s taken up by DCs to lymph nodes
What happens in the third phase of the elimination phase?
CD4 T cells and CD8 T cells are recruited
What happens in the fourth phase of the elimination phase?
-Tumor specific CD4 and CD8 T cells attempt to destroy remaining antigen bearing tumor cells
