3/3/17 GERMAN T Cell Development TEST #2

Question 1

Where do T-cell progenitors develop?

Answer 1

-Bone marrow

Question 2

Where does positive and negative selection for T cells occur?

Answer 2

-Thymus

Question 3

What are developing T cells within the thymus called?

Answer 3

-Thymocytes

Question 4

What type of T cells do not express CD4 or CD4 co receptors?

Answer 4

-Gamma:Delta T cells

Question 5

Where does TCR development occur within the thymus?

Answer 5

-Cortex

Question 6

As the T cell matures from a double negative to a double positive where does it move from and to within the thymus?

Answer 6

-Cortex to medulla

Question 7

T/F The thymus involutes with age

Answer 7

True

Question 8

What is the half life for a CD4 cell?

Answer 8

4.2 years

Question 9

What is the half life for a CD8 cell?

Answer 9

-6.5 yrs

Question 10

T/F T cell progenitors don’t commit until they reach the thymus

Answer 10

True

Question 11

T cells determine they are in the right spot by what type of signaling?

Answer 11

Notch 1

Question 12

What is a B cell transcription factor?

Answer 12

-Pax-5

Question 13

What type of T cell is a double-negative?

Answer 13

-Pre-T cell

Question 14

If a T cell rearranges the Gamma:Delta before the Beta what type of T cell does it become?

Answer 14

-Gamma:Delta T cell

Question 15

If a T cell rearranges the Beta chain first what type of T cell does it become?

Answer 15

-Alpha:Beta T cell

Question 16

What is the first checkpoint for T cell development?

Answer 16

-Having a Pre-T cell receptor

Question 17

What is the second checkpoint for T cell development?

Answer 17

-Positive and Negative selection

Question 18

After you have proliferating pre-T cells what is the next stage of T cell development?

Answer 18

-Double positive

Question 19

After you undergo positive and negative selection of T cells, what is the next stage of development?

Answer 19

-Single-positive

Question 20

What dictates T cell lineage?

Answer 20

-Gene rearrangement

Question 21

If you are going to become and Alpha:Beta T cell what is the first chain that needs to be rearranged?

Answer 21

-Beta chain

Question 22

Beta chain production drives the expression of what?

Answer 22

• CD4

- CD8

Question 23

What two regions come together first in the B-chain rearrangement?

Answer 23

-DJ

Question 24

What type of T cell development stage does the Beta chain rearrangement occur?

Answer 24

-Double negative

Question 25

What forms Pre-T cell receptors?

Answer 25

-Beta chian rearrangement

Question 26

When the B chain binds a surrogate alpha chain and creates a super dimer what is recruited?

Answer 26

-CD3 complex

Question 27

Once the Beta chain has rearranged can the cell still become a Gamma:Delta T cell?

Answer 27

-Yes

Question 28

In a double negative thymocyte will you have CD4 or CD8?

Answer 28

-No

Question 29

In a double positive thymocyte will you have CD4 or CD8?

Answer 29

-Yes both

Question 30

What does positive T cell selection lead to?

Answer 30

-Function TCR

Question 31

What does Negative T cell selection lead to?

Answer 31

-No self-antigen binding

Question 32

What does positive selection ensure?

Answer 32

-MHC is bound

Question 33

In the positive selection process a TCR must bind the MHC within how many days or else it will DIE!!!

Answer 33

3 to 4 days

Question 34

What is the last type of selection that occurs before a T cell gets released into the periphery?

Answer 34

-Negative selection

Question 35

Dendritic cells and macrophages present self peptides to T-cells, if it binds excessively what occurs?

Answer 35

-Apoptosis

Question 36

Where do mature naive T cells enter?

Answer 36

-Blood stream

Question 37

What are the two major stages of T cell development?

Answer 37

• Double Negative

- Double Positive

Question 38

When a T cell is a double negative what occurs?

Answer 38

-Beta chain rearrangment