4/25/17 Adaptive immune diseases GERMAN FINAL TEST Flashcards
Autoimmune Diseases are loss of ____ leading to hypersensitivity reactions.
-Tolerance
What type of selection in B cells contribute to self-tolerance?
-Negative selection
What types of hypersensitivity reactions are involved in Autoimmune Diseases?
- Type II
- Type III
- Type IV
AD’s are caused by what two things?
- Genetics
- Environments
- Both
_____ subtype influences AD development.
-HLA
HLA genes are associated with susceptibility in what percent of ADs?
50%
What class of alleles are most frequently implicated in ADs?
-Class II
Grave’s disease is associated with what type of hypersensitivity?
-Type II
Type 2 Diabetes is associated with what type of hypersensitivity?
-Type II
Rheumatic Fever is caused by what?
-Molecular mimicry
Transient responses due to lack of T cell help is associated with what disease?
-Rheumatic Fever
T/F S. pyogenes cell wall shares human epitopes
True
What type of hypersensitivity is Rheumatic fever?
Type II
Graves disease is associated with antibody binding that causes what?
-Metabolic Dysfunction
What disease is associated with excessive thyroid hormone release (Hyperthyroidism)?
-Graves disease
What do antibodies in graves disease function as?
-Thyroid stimulating hormone agonist
T/F If a mother has grave’s disease she can pass it during pregnancy to the baby
True
What disease is associated with the destruction of normal thyroid tissue (hypothyroidism, the thyroid looks enlarged though)?
-Hashimoto’s disease
What type of hypersensitivity is Hashimoto’s disease associated with?
-Type II
What disease is associated with salivary gland enlargement, Glossitis, and mouth breathing?
-Hypothyroidism
What disease is associated with increased susceptibility to caries, enlargement of extra glandular thyroid tissue, and has accelerated dental eruption?
-Hyperthyroidism
What disease is associated with progressive destruction of the exocrine glands?
-Sjogren’s syndrome
Who is Sjogren’s syndrome more prevalent in?
-Women
What type of hypersensitivity is Sjogren’s syndrome?
-Type II
What are some signs of Sjogren’s syndrome?
- Dry eyes, mouth
- Oral Candidiasis
What type of hypersensitivity is associated with systemic lupus erythematosus?
-Type III
If you have mouth ulcers and plaques, deposits in blood vessels kidney and joints what disease is that associated with?
-Systemic lupus erythematosus
What does Systemic Lupus cause?
-Intermolecular epitope spreading
T/F SLE leads to a loss of tolerance
True
T/F Intermolecular epitope spreading is different proteins being targeted from one initial protein while intramolecular is one small conserved region of a protein shares an epitope with a pathogen and now an entire protein can be targeted.
True
What type of hypersensitivity is celiac disease?
-Type IV
T/F Thymic involution is tied to increase AD incidence
True
Type I diabetes is what type of hypersensitivity reaction
-Type IV
In Type I diabetes autoimmunity what kills the Beta cells?
CD4 aand CD8 T cells
What are some oral manifestations seen in autoimmune type I diabetics?
- Sweet breath
- Impaired wound healing
- Altered saliva composition
- Reduced salivary flow
