3/31/17 NK cells and Gamma Delta T cells GERMAN TEST #3

Question 1

What type of cells to NK cells kill?

Answer 1

-Diseased and dysfunction self cells

Question 2

What are NK cells regulated by?

Answer 2

-Interactions with MHC I molecules

Question 3

NK cells recognize targets how?

Answer 3

-The target cells lack of MHC I

Question 4

What are the three cell states that regulate NK cell targeting?

Answer 4

• Protection
• Missing-self
• Induced-self

Question 5

What cell state is a healthy cell that express both stimulating and inhibitory signals?

Answer 5

-Protection

Question 6

What cell state is an unhealthy cell with reduced MHC I expression?

Answer 6

-Missing-self

Question 7

What cell state is an unhealthy cell with increase stress ligand expression?

Answer 7

-Induced self

Question 8

What are the activating receptors for NK cells?

Answer 8

• NKG2D

- CD16 (Fc receptor)

Question 9

What are the inhibitory receptors for NK cells?

Answer 9

• NKG2A

- KIR family

Question 10

Which receptors for NK cells are lectin like?

Answer 10

• NKG2D

- NKG2A

Question 11

What ligand structure is involved in CD16 receptors?

Answer 11

-Immunoglobulin

Question 12

What ligand structure is involved in NKG2D, NKG2A, and the KIR family receptors?

Answer 12

-MHC class I

Question 13

What are the three major receptor families involved in NK cells?

Answer 13

• CD 16
• NKG family
• KIR family

Question 14

What NK receptor is a low affinity IgG Fc receptor, and an activating receptor?

Answer 14

-CD 16

Question 15

What NK receptor is an activating receptor that binds MIC proteins?

Answer 15

-NKG2D

Question 16

What NK receptor detects healthy self tissue?

Answer 16

-KIR family

Question 17

T/F Cells usually express NKG2A or KIR receptor but not both

Answer 17

True

Question 18

What does the detection of MHC I by NK cells prevent?

Answer 18

Killing

Question 19

What three things are involved in NK cell activation?

Answer 19

• Target cell interaction
• Leukocyte interaction
• Cytokines

Question 20

What cytokines are involved in NK cell activation?

Answer 20

• IFN

- IL-12

Question 21

What are the three target cell interactions that help with NK cell activation?

Answer 21

• Downregulated MHC I
• Stress ligands
• CD16

Question 22

How many signals are required to activate Nk cells from the innate immune system?

Answer 22

two

Question 23

How many signals are required to activate NK cells from the adaptive immune system?

Answer 23

-One

Question 24

Which immune system that activates NK cells deals with Ig targeting?

Answer 24

-Adaptive

Question 25

Which immune system that activates NK cells deals with Stress ligands?

Answer 25

-Innate

Question 26

What three things are involved in NK cell cytotoxicity?

Answer 26

• Degranulation
• Death-receptors
• Interferons and Nitiric Oxide

Question 27

What are two death-receptors involved in NK cell cytotoxicity?

Answer 27

• FasL

- TRAIL

Question 28

What do Gamma:Delta t cells monitor?

Answer 28

-Tissue health

Question 29

What is the major role of Gamma:Delta T cells?

Answer 29

-Remove diseased an malignant cells

Question 30

What unique antigens to Gamma:delta T cells bind?

Answer 30

• Phosphoantigens
• Phospholipids
• Lipids

Question 31

T/F Gamma:Delta T cells can migrate to lymph nodes and function as an APC cell

Answer 31

true

Question 32

T/F CD1 can interact with Gamma:Delta T cells

Answer 32

True