3/31/17 NK cells and Gamma Delta T cells GERMAN TEST #3 Flashcards
What type of cells to NK cells kill?
-Diseased and dysfunction self cells
What are NK cells regulated by?
-Interactions with MHC I molecules
NK cells recognize targets how?
-The target cells lack of MHC I
What are the three cell states that regulate NK cell targeting?
- Protection
- Missing-self
- Induced-self
What cell state is a healthy cell that express both stimulating and inhibitory signals?
-Protection
What cell state is an unhealthy cell with reduced MHC I expression?
-Missing-self
What cell state is an unhealthy cell with increase stress ligand expression?
-Induced self
What are the activating receptors for NK cells?
- NKG2D
- CD16 (Fc receptor)
What are the inhibitory receptors for NK cells?
- NKG2A
- KIR family
Which receptors for NK cells are lectin like?
- NKG2D
- NKG2A
What ligand structure is involved in CD16 receptors?
-Immunoglobulin
What ligand structure is involved in NKG2D, NKG2A, and the KIR family receptors?
-MHC class I
What are the three major receptor families involved in NK cells?
- CD 16
- NKG family
- KIR family
What NK receptor is a low affinity IgG Fc receptor, and an activating receptor?
-CD 16
What NK receptor is an activating receptor that binds MIC proteins?
-NKG2D
What NK receptor detects healthy self tissue?
-KIR family
T/F Cells usually express NKG2A or KIR receptor but not both
True
What does the detection of MHC I by NK cells prevent?
Killing
What three things are involved in NK cell activation?
- Target cell interaction
- Leukocyte interaction
- Cytokines
What cytokines are involved in NK cell activation?
- IFN
- IL-12
What are the three target cell interactions that help with NK cell activation?
- Downregulated MHC I
- Stress ligands
- CD16
How many signals are required to activate Nk cells from the innate immune system?
two
How many signals are required to activate NK cells from the adaptive immune system?
-One
Which immune system that activates NK cells deals with Ig targeting?
-Adaptive
Which immune system that activates NK cells deals with Stress ligands?
-Innate
What three things are involved in NK cell cytotoxicity?
- Degranulation
- Death-receptors
- Interferons and Nitiric Oxide
What are two death-receptors involved in NK cell cytotoxicity?
- FasL
- TRAIL
What do Gamma:Delta t cells monitor?
-Tissue health
What is the major role of Gamma:Delta T cells?
-Remove diseased an malignant cells
What unique antigens to Gamma:delta T cells bind?
- Phosphoantigens
- Phospholipids
- Lipids
T/F Gamma:Delta T cells can migrate to lymph nodes and function as an APC cell
true
T/F CD1 can interact with Gamma:Delta T cells
True
