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Host and Defense 2020 > 3/16/17 CLAYTON Pathology of inflammation TEST #3 > Flashcards

3/16/17 CLAYTON Pathology of inflammation TEST #3 Flashcards

1
Q

T/F Injury caues inflammation

A

True

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2
Q 
Which of the following injuries cause inflammation?
A) Infection
B) Trauma, radiation
C) Chemical injury
D) Autoimmunity
E) Tumors
F) All of the above
A

F) all of the above

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3
Q

What pattern of inflammation begins almost immediately and lasts minutes to days?

A

-Acute

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4
Q

What are the main cells in acute inflammation?

A
  • Neutrophils
  • Vessels
  • Mast Cells
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5
Q

What pattern of inflammation begins at least 6 hours to days later?

A

-chronic

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6
Q

What are the main cells involved in chronic inflammation?

A
  • Lymphocytes
  • Macrophages
  • Plasma cells
  • Fibroblasts
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7
Q

What pattern of inflammation is a variant of chronic inflammation?

A

-Granulomatous

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8
Q

What cells do you find in granulomatous inflammation?

A
  • Aggregates of epithelioid histiocytes/macrophages
  • Giant cells
  • Lymphocytes
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9
Q

Rubor (redness), Tumor (Swelling) and Calor (warmth) are caused from what in inflammation?

A

-From leaky small blood vessels

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10
Q

Dolor (pain) in inflammation is caused by what?

A
  • PgE2
  • Bradykinin
  • substance P
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11
Q

In pus found with an abscess what will you see in it?

A

-Many neutrophils (acute inflammation)

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12
Q

T/F Vessels are crucial in inflammation

A

True

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13
Q

Small vessels develop what in inflammation?

A

-Endothelial cell retraction and pinocytosis

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14
Q

What is a fluid that has a lot of plasma and is rich in proteins in it?

A

-Exudate

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15
Q

If you have a lower specific gravity, protein and LDH do you have transudate or exudate?

A

-Transudate

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16
Q

If you have a hemodynamic problem will you have transudate or exudate?

A

-Transudate

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17
Q

If you see leukocytosis with neutrophilia in lab signs of inflammation will you have acute or chronic inflammation?

A

-Acute (think bacterial infection)

18
Q

If you have leukocytosis with lymphocytosis in lab signs of inflammation will you have chronic or acute inflammation?

A

-Chronic (think viral)

19
Q

If you are seeing neutrophils that are depleted and then have bands (immature neutrophils) will you more likely have chronic or acute inflammation?

A

-Acute

20
Q

If you have eosinophilia what is that commonly associated with?

A
  • Parasitic infection
  • Autoimmune
  • Asthma/allergic
21
Q 
What type of response is eosinophilia?
A) Type I
B) Type II
C) Type III
D) Type IV?
A

-B) Type II

22
Q

If you have inflammation, will you have an increased or decreased sedimentation rate?

A

-Increased

23
Q

T/F Fibrinogen is an acute phase reactant made in the liver

A

True

24
Q

T/F When you have increased sedimentation rate you will have increased plasma fibrinogen, red cells will clump and sink faster

A

True

25
Q

Besides fibrinogen what are three other acute phase reactants associated with inflammation?

A
  • CRP (C reactive protein)
  • Procalcitonin
  • SAA (serum amyloid A protein)
  • Cerulopasmin (copper binding protein)
26
Q

What acute phase reactant is largely specific for bacterial infection?

A

-Procalcitonin

27
Q

If you have mild increases of CRP in healthy subjects what can that indicate the risk of?

A

-Atherosclerosis

28
Q

What acute phase reactant can help determine if antibiotics are needed?

A

-Procalcitonin

29
Q

In vascular changes in inflammation will you see vasoconstriction or vasodilation?

A

-Vasodilation

30
Q

ARDS is an exudate or transudate?

A

-Exudate

31
Q

Pulmonary edema is a transudate or exudate?

A

-Transudate

32
Q

CD4 TH2 cells are used for what?

A
  • Parasitic infections

- Allergies

33
Q

TH17 cells are for what?

A

-Ongoing neutrophil infiltrates

34
Q

CD4 TH1 are for what?

A

Fungal, mycobacterial and other infections

35
Q

What is a granuloma?

A

-Cluster of epithelioid macrophages

36
Q

T/F Granulomas can calcify

A

True

37
Q

T/F Infections and foreign bodies can cause granulomas

A

True

38
Q

A type II immune response occurs in response to what?

A
  • Parasites

- Allergic-like diseases

39
Q

What cells do you have in in a type II immune response?

A
  • Th2 lymphocytes
  • eosinophils
  • mast cells
  • basophils
40
Q

What is the rarest of the blood leukocytes?

A

-Basophil

41
Q

Basophils like mast calls are coated with what Ig?

A

-IgE

42
Q

With asthma what cells might you see in the bronchial mucosa?

A

-Eosinophils

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