3/3/17 GERMAN T Cell Receptors, MHC, and Antigen binding TEST #2 Flashcards
What type of T cell kills virus-infected cells?
-CD8 Cytotoxic T cells
What do CD4 T regulatory cells do?
-Suppress T-cell responses
What T cell type activates infected macrophages and provide help to B cells for antibody production?
-CD4 TH1 cells
What T cell type provides help to B cells for antibody production, especially switching to IgE?
-CD4 TH2 cells
What type of T cell enhances neutrophil response and promotes barrier integrity?
-CD4 TH17
What type of T cells are B cell helpers, isotype switching and in antibody production?
-TFH cells
What are T cells define by?
-T cell receptors
What do T cells bind primarily?
-Polypeptides
T/F The T cell receptor is secreted and not expressed on the cell surface.
False
- It is never secreted
- It is expressed on the cell surface
T/F T cells have an effector function
False
-No effector function
The T cells interact with what complex?
-MHC presented antigen
What are the two classes of T cell receptors?
- Alpha:Beta T cells
- Gamma: Delta T cells
What type of T cell class is involved in the adaptive immunity?
-Alpha:Beta T cells
What class of T cells are common in tissues not in circulation?
-Gamma:Delta T cells
What class of T cell is common in circulation and not in tissues?
-Alpha:Beta T cells
What class of T cell monitors tissue health?
-Gamma:Delta T cells
What class of T cells develop, but do not mature in the thymus?
-Gamma:Delta T cells
What class of T cells develop and mature in the thymus?
-Alpha:Beta T cells
Which class of T cells have limited positive and negative selection?
-Gamma:Delta T cells
T/F T cells only express on type of class, never both
True
Which class of T cells are not involved in classic adaptive immunity?
-Gamma:Delta T cells
TCR have what two chains?
- Alpha
- Beta
What segments do you find on the alpha chain?
-V, J, C segments
What segments do you find on the Beta chain?
-V, J, D, C segments
If you have a deficiency in RAG proteins what might happen to the individual?
-Immunodeficient in T cell receptors and antibodies
SCIDS
What chain in T cells undergoes recombination first?
-Beta chain
Do you have more diversity with T cell receptors or immunoglobulins?
-T cells
Plasma membrane TCR expression does not occur without what complex?
-CD3 complex
What does the CD3 complex mediate?
-TCR signaling
What presents antigens to TCRs?
-MHC
What cells is MHC class I expressed on?
-Nearly all cells
What cells is MHC class II expressed on?
- Macrophages
- Dendritic cells
- B cells
What antigens do MHC class I recognize?
-Intracellular antigen
What antigens to MHC class II recognize?
-Internalized antigen (something in a phagosome/lysosome)
What loads the MHC class II?
-Vesicular ER loading
What loads the MHC class I?
-ER antigen loading
What allows the binding between the MHC class I and the TCR?
-CD8 co-receptor
What allows the binding between MHC class II and the TCR?
-CD4 co-receptor
If there is no co-receptor found on the MHC which class with the TCR bind?
-Both
MHC is also referred to as what?
Human Leukocyte Antigen complex
What breaks down the antigen in MHC class I?
-Proteasome
What class of cells don’t express MHC class I?
-Erythrocytes
T/F Macrophages can have the expression of both MHC class I and MHC class II
True
Where is MHC class I produced?
-Endoplasmic reticulm
Small peptides are delivered into the ER by TAP, once they are bound to MHC class I and it becomes mature what happens?
THe mature MHC class I is exported from the ER
T/F MHC class I can do crosspresentation of an endocytosed antigen that is typically presented by MHC class II.
True
In MCH class II expression what do the MCH class II molecules bind to?
-Vesicles containing peptides
What in MHC II prevents self antigen presentation?
-CLIP
What dictates MHC specificity?
-Co-receptors
T/F T cells have direct and indirect effector function.
True
