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Host and Defense 2020 > 3/3/17 GERMAN T Cell Receptors, MHC, and Antigen binding TEST #2 > Flashcards

3/3/17 GERMAN T Cell Receptors, MHC, and Antigen binding TEST #2 Flashcards

1
Q

What type of T cell kills virus-infected cells?

A

-CD8 Cytotoxic T cells

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2
Q

What do CD4 T regulatory cells do?

A

-Suppress T-cell responses

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3
Q

What T cell type activates infected macrophages and provide help to B cells for antibody production?

A

-CD4 TH1 cells

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4
Q

What T cell type provides help to B cells for antibody production, especially switching to IgE?

A

-CD4 TH2 cells

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5
Q

What type of T cell enhances neutrophil response and promotes barrier integrity?

A

-CD4 TH17

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6
Q

What type of T cells are B cell helpers, isotype switching and in antibody production?

A

-TFH cells

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7
Q

What are T cells define by?

A

-T cell receptors

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8
Q

What do T cells bind primarily?

A

-Polypeptides

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9
Q

T/F The T cell receptor is secreted and not expressed on the cell surface.

A

False

  • It is never secreted
  • It is expressed on the cell surface
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10
Q

T/F T cells have an effector function

A

False

-No effector function

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11
Q

The T cells interact with what complex?

A

-MHC presented antigen

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12
Q

What are the two classes of T cell receptors?

A
  • Alpha:Beta T cells

- Gamma: Delta T cells

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13
Q

What type of T cell class is involved in the adaptive immunity?

A

-Alpha:Beta T cells

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14
Q

What class of T cells are common in tissues not in circulation?

A

-Gamma:Delta T cells

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15
Q

What class of T cell is common in circulation and not in tissues?

A

-Alpha:Beta T cells

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16
Q

What class of T cell monitors tissue health?

A

-Gamma:Delta T cells

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17
Q

What class of T cells develop, but do not mature in the thymus?

A

-Gamma:Delta T cells

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18
Q

What class of T cells develop and mature in the thymus?

A

-Alpha:Beta T cells

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19
Q

Which class of T cells have limited positive and negative selection?

A

-Gamma:Delta T cells

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20
Q

T/F T cells only express on type of class, never both

A

True

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21
Q

Which class of T cells are not involved in classic adaptive immunity?

A

-Gamma:Delta T cells

22
Q

TCR have what two chains?

A
  • Alpha

- Beta

23
Q

What segments do you find on the alpha chain?

A

-V, J, C segments

24
Q

What segments do you find on the Beta chain?

A

-V, J, D, C segments

25
Q

If you have a deficiency in RAG proteins what might happen to the individual?

A

-Immunodeficient in T cell receptors and antibodies

SCIDS

26
Q

What chain in T cells undergoes recombination first?

A

-Beta chain

27
Q

Do you have more diversity with T cell receptors or immunoglobulins?

A

-T cells

28
Q

Plasma membrane TCR expression does not occur without what complex?

A

-CD3 complex

29
Q

What does the CD3 complex mediate?

A

-TCR signaling

30
Q

What presents antigens to TCRs?

A

-MHC

31
Q

What cells is MHC class I expressed on?

A

-Nearly all cells

32
Q

What cells is MHC class II expressed on?

A
  • Macrophages
  • Dendritic cells
  • B cells
33
Q

What antigens do MHC class I recognize?

A

-Intracellular antigen

34
Q

What antigens to MHC class II recognize?

A

-Internalized antigen (something in a phagosome/lysosome)

35
Q

What loads the MHC class II?

A

-Vesicular ER loading

36
Q

What loads the MHC class I?

A

-ER antigen loading

37
Q

What allows the binding between the MHC class I and the TCR?

A

-CD8 co-receptor

38
Q

What allows the binding between MHC class II and the TCR?

A

-CD4 co-receptor

39
Q

If there is no co-receptor found on the MHC which class with the TCR bind?

A

-Both

40
Q

MHC is also referred to as what?

A

Human Leukocyte Antigen complex

41
Q

What breaks down the antigen in MHC class I?

A

-Proteasome

42
Q

What class of cells don’t express MHC class I?

A

-Erythrocytes

43
Q

T/F Macrophages can have the expression of both MHC class I and MHC class II

A

True

44
Q

Where is MHC class I produced?

A

-Endoplasmic reticulm

45
Q

Small peptides are delivered into the ER by TAP, once they are bound to MHC class I and it becomes mature what happens?

A

THe mature MHC class I is exported from the ER

46
Q

T/F MHC class I can do crosspresentation of an endocytosed antigen that is typically presented by MHC class II.

A

True

47
Q

In MCH class II expression what do the MCH class II molecules bind to?

A

-Vesicles containing peptides

48
Q

What in MHC II prevents self antigen presentation?

A

-CLIP

49
Q

What dictates MHC specificity?

A

-Co-receptors

50
Q

T/F T cells have direct and indirect effector function.

A

True

Host and Defense 2020 (61 decks)

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