3/3/17 GERMAN T Cell Receptors, MHC, and Antigen binding TEST #2

Question 1

What type of T cell kills virus-infected cells?

Answer 1

-CD8 Cytotoxic T cells

Question 2

What do CD4 T regulatory cells do?

Answer 2

-Suppress T-cell responses

Question 3

What T cell type activates infected macrophages and provide help to B cells for antibody production?

Answer 3

-CD4 TH1 cells

Question 4

What T cell type provides help to B cells for antibody production, especially switching to IgE?

Answer 4

-CD4 TH2 cells

Question 5

What type of T cell enhances neutrophil response and promotes barrier integrity?

Answer 5

-CD4 TH17

Question 6

What type of T cells are B cell helpers, isotype switching and in antibody production?

Answer 6

-TFH cells

Question 7

What are T cells define by?

Answer 7

-T cell receptors

Question 8

What do T cells bind primarily?

Answer 8

-Polypeptides

Question 9

T/F The T cell receptor is secreted and not expressed on the cell surface.

Answer 9

False

• It is never secreted
• It is expressed on the cell surface

Question 10

T/F T cells have an effector function

Answer 10

False

-No effector function

Question 11

The T cells interact with what complex?

Answer 11

-MHC presented antigen

Question 12

What are the two classes of T cell receptors?

Answer 12

• Alpha:Beta T cells

- Gamma: Delta T cells

Question 13

What type of T cell class is involved in the adaptive immunity?

Answer 13

-Alpha:Beta T cells

Question 14

What class of T cells are common in tissues not in circulation?

Answer 14

-Gamma:Delta T cells

Question 15

What class of T cell is common in circulation and not in tissues?

Answer 15

-Alpha:Beta T cells

Question 16

What class of T cell monitors tissue health?

Answer 16

-Gamma:Delta T cells

Question 17

What class of T cells develop, but do not mature in the thymus?

Answer 17

-Gamma:Delta T cells

Question 18

What class of T cells develop and mature in the thymus?

Answer 18

-Alpha:Beta T cells

Question 19

Which class of T cells have limited positive and negative selection?

Answer 19

-Gamma:Delta T cells

Question 20

T/F T cells only express on type of class, never both

Answer 20

True

Question 21

Which class of T cells are not involved in classic adaptive immunity?

Answer 21

-Gamma:Delta T cells

Question 22

TCR have what two chains?

Answer 22

• Alpha

- Beta

Question 23

What segments do you find on the alpha chain?

Answer 23

-V, J, C segments

Question 24

What segments do you find on the Beta chain?

Answer 24

-V, J, D, C segments

Question 25

If you have a deficiency in RAG proteins what might happen to the individual?

Answer 25

-Immunodeficient in T cell receptors and antibodies | SCIDS

Question 26

What chain in T cells undergoes recombination first?

Answer 26

-Beta chain

Question 27

Do you have more diversity with T cell receptors or immunoglobulins?

Answer 27

-T cells

Question 28

Plasma membrane TCR expression does not occur without what complex?

Answer 28

-CD3 complex

Question 29

What does the CD3 complex mediate?

Answer 29

-TCR signaling

Question 30

What presents antigens to TCRs?

Answer 30

-MHC

Question 31

What cells is MHC class I expressed on?

Answer 31

-Nearly all cells

Question 32

What cells is MHC class II expressed on?

Answer 32

- Macrophages - Dendritic cells - B cells

Question 33

What antigens do MHC class I recognize?

Answer 33

-Intracellular antigen

Question 34

What antigens to MHC class II recognize?

Answer 34

-Internalized antigen (something in a phagosome/lysosome)

Question 35

What loads the MHC class II?

Answer 35

-Vesicular ER loading

Question 36

What loads the MHC class I?

Answer 36

-ER antigen loading

Question 37

What allows the binding between the MHC class I and the TCR?

Answer 37

-CD8 co-receptor

Question 38

What allows the binding between MHC class II and the TCR?

Answer 38

-CD4 co-receptor

Question 39

If there is no co-receptor found on the MHC which class with the TCR bind?

Answer 39

-Both

Question 40

MHC is also referred to as what?

Answer 40

Human Leukocyte Antigen complex

Question 41

What breaks down the antigen in MHC class I?

Answer 41

-Proteasome

Question 42

What class of cells don't express MHC class I?

Answer 42

-Erythrocytes

Question 43

T/F Macrophages can have the expression of both MHC class I and MHC class II

Answer 43

True

Question 44

Where is MHC class I produced?

Answer 44

-Endoplasmic reticulm

Question 45

Small peptides are delivered into the ER by TAP, once they are bound to MHC class I and it becomes mature what happens?

Answer 45

THe mature MHC class I is exported from the ER

Question 46

T/F MHC class I can do crosspresentation of an endocytosed antigen that is typically presented by MHC class II.

Answer 46

True

Question 47

In MCH class II expression what do the MCH class II molecules bind to?

Answer 47

-Vesicles containing peptides

Question 48

What in MHC II prevents self antigen presentation?

Answer 48

-CLIP

Question 49

What dictates MHC specificity?

Answer 49

-Co-receptors

Question 50

T/F T cells have direct and indirect effector function.

Answer 50

True