3/31/17 Mucosal Immunity GERMAn TEST #3

Question 1

What is the most common cause of worldwide deaths from mucosal infections?

Answer 1

-Acute respiratory infections

Question 2

What are three places in the body where you find mucosal tissues?

Answer 2

• Respiratory tract
• GI tract
• Urogenital tract

Question 3

What three conserved structures do all mucosal tissues exhibit?

Answer 3

• Epithelium
• Lamina propria
• Mucosal-associated lymphoid tissue

Question 4

What compartment of the mucosal structures do you find intraepithelial lymphocytes?

Answer 4

-Epithelium

Question 5

What are three examples of intraepithelial lymphocytes?

Answer 5

• Delta:Gamma T cells
• CD8 alpha:alpha T cells
• Memory CD8 T cells

Question 6

What three lymphocyte type cells will you find in the lamina propria?

Answer 6

• Gamma:Delta T cells
• CD8 T cells
• CD4 T cells

Question 7

What CD4 T cells will you find in the lamina propria?

Answer 7

• TH1

- TH17

Question 8

What compartment of the mucosal structures do you find plasma cells and memory B cells, Macrophages, and dendritic cells?

Answer 8

-Lamina Propria

Question 9

What is the ring name of the tonsils and adenoids around the entrance of the gut and airway?

Answer 9

-Waldeyer’s ring

Question 10

What is healthy tissue protected by?

Answer 10

-Systemic immunity

Question 11

When you have a surface wound that introduces bacteria it activates macrophages to make what?

Answer 11

-Inflammatory cytokines

Question 12

What do cytokines released from macrophages produce?

Answer 12

-Inflammatory immune response

Question 13

T/F Mucosal infections follow the traditional inflammatory cascade

Answer 13

False

-They do not follow

Question 14

How do bacteria gain access to the lamina propria?

Answer 14

-Endocytosis

Question 15

Most infections are often cleared with or without an inflammatory response?

Answer 15

-without

Question 16

What are the secretory antibodies of mucosal surfaces?

Answer 16

-IgA

Question 17

Naive lymphocytes activated in a Peyer’s patch give rise to effector cells that travel in the lymph and blood to gain access to what compartment of the mucosal tissue?

Answer 17

-Lamina propria

Question 18

If you have periodontal health do you have high or low diversity and richness?

Answer 18

-Low diversity and richness

Question 19

Where are antigens taken up in mucosal surfaces?

Answer 19

• Peyer’s patch

- Lymphoid follicles

Question 20

T/F The microbiome influences CD4 T cell differentiation

Answer 20

-True

Question 21

What cytokine is prominent at mucosal surfaces?

Answer 21

-TGF-Beta

Question 22

If you have TGF Beta + no inflammatory cytokines what T cell will you get?

Answer 22

-T reg cells

Question 23

If you have TGF-Beta + inflammatory cytokines what T cells will you get?

Answer 23

-Th17

Question 24

What do T reg cells do for mucosal inflammation?

Answer 24

-Treg

Question 25

What do Th17 cells do for mucosal tissue?

Answer 25

- Neutrophil recruitment - Antimicrobial peptide production - Tissue repair

Question 26

What cytokines do Th17 cells release?

Answer 26

- IL-17 | - IL-22

Question 27

What three functions do the cytokines that Th17 releases play in mucosal tissues?

Answer 27

- Regulate tight junction protein expression - Induce antimicrobial peptide production - Induce neutrophil chemokine expression

Question 28

What three things are found in the function of Th17 that deals with inducing antimicrobial peptide production?

Answer 28

- B-defensins - Cathelicidins - Lactoferrin

Question 29

T/F Impaired or excessive Th17 function is linked to oral disease

Answer 29

True

Question 30

If you have increased IL-17 expression what oral disease might that be involved in?

Answer 30

-Periodontitis

Question 31

If you have deficient IL-17 signaling what oral disease is that associated with?

Answer 31

-Chronic mucocutaneous candidiasis

Question 32

If you have periodontitis what happens with neutrophil recruitment?

Answer 32

-It is chronic and excessive

Question 33

What happens to osteoclasts in periodontitis?

Answer 33

-They become activated

Question 34

What are three ways that mucosal antigens are captured?

Answer 34

- Macrophage - Goblet cells - Dendritic cells

Question 35

What do commensal bacteria do for an immune response?

Answer 35

-Repress

Question 36

What do pathogenic bacteria do for an immune response?

Answer 36

-Trigger

Question 37

What cell with mucosal antigens deals with nonspecific transport across epithelium?

Answer 37

-M cell

Question 38

T/F Mucosal epithelial cells express TLR and NOD receptors

Answer 38

True

Question 39

T/F Epithelial damage can promote mucosal inflammation

Answer 39

True (Via antibiotics killing commensal bacteria making room for C. diff)