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Host and Defense 2020 > 3/31/17 Mucosal Immunity GERMAn TEST #3 > Flashcards

3/31/17 Mucosal Immunity GERMAn TEST #3 Flashcards

1
Q

What is the most common cause of worldwide deaths from mucosal infections?

A

-Acute respiratory infections

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2
Q

What are three places in the body where you find mucosal tissues?

A
  • Respiratory tract
  • GI tract
  • Urogenital tract
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3
Q

What three conserved structures do all mucosal tissues exhibit?

A
  • Epithelium
  • Lamina propria
  • Mucosal-associated lymphoid tissue
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4
Q

What compartment of the mucosal structures do you find intraepithelial lymphocytes?

A

-Epithelium

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5
Q

What are three examples of intraepithelial lymphocytes?

A
  • Delta:Gamma T cells
  • CD8 alpha:alpha T cells
  • Memory CD8 T cells
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6
Q

What three lymphocyte type cells will you find in the lamina propria?

A
  • Gamma:Delta T cells
  • CD8 T cells
  • CD4 T cells
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7
Q

What CD4 T cells will you find in the lamina propria?

A
  • TH1

- TH17

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8
Q

What compartment of the mucosal structures do you find plasma cells and memory B cells, Macrophages, and dendritic cells?

A

-Lamina Propria

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9
Q

What is the ring name of the tonsils and adenoids around the entrance of the gut and airway?

A

-Waldeyer’s ring

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10
Q

What is healthy tissue protected by?

A

-Systemic immunity

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11
Q

When you have a surface wound that introduces bacteria it activates macrophages to make what?

A

-Inflammatory cytokines

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12
Q

What do cytokines released from macrophages produce?

A

-Inflammatory immune response

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13
Q

T/F Mucosal infections follow the traditional inflammatory cascade

A

False

-They do not follow

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14
Q

How do bacteria gain access to the lamina propria?

A

-Endocytosis

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15
Q

Most infections are often cleared with or without an inflammatory response?

A

-without

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16
Q

What are the secretory antibodies of mucosal surfaces?

A

-IgA

17
Q

Naive lymphocytes activated in a Peyer’s patch give rise to effector cells that travel in the lymph and blood to gain access to what compartment of the mucosal tissue?

A

-Lamina propria

18
Q

If you have periodontal health do you have high or low diversity and richness?

A

-Low diversity and richness

19
Q

Where are antigens taken up in mucosal surfaces?

A
  • Peyer’s patch

- Lymphoid follicles

20
Q

T/F The microbiome influences CD4 T cell differentiation

A

-True

21
Q

What cytokine is prominent at mucosal surfaces?

A

-TGF-Beta

22
Q

If you have TGF Beta + no inflammatory cytokines what T cell will you get?

A

-T reg cells

23
Q

If you have TGF-Beta + inflammatory cytokines what T cells will you get?

A

-Th17

24
Q

What do T reg cells do for mucosal inflammation?

A

-Treg

25
Q

What do Th17 cells do for mucosal tissue?

A
  • Neutrophil recruitment
  • Antimicrobial peptide production
  • Tissue repair
26
Q

What cytokines do Th17 cells release?

A
  • IL-17

- IL-22

27
Q

What three functions do the cytokines that Th17 releases play in mucosal tissues?

A
  • Regulate tight junction protein expression
  • Induce antimicrobial peptide production
  • Induce neutrophil chemokine expression
28
Q

What three things are found in the function of Th17 that deals with inducing antimicrobial peptide production?

A
  • B-defensins
  • Cathelicidins
  • Lactoferrin
29
Q

T/F Impaired or excessive Th17 function is linked to oral disease

A

True

30
Q

If you have increased IL-17 expression what oral disease might that be involved in?

A

-Periodontitis

31
Q

If you have deficient IL-17 signaling what oral disease is that associated with?

A

-Chronic mucocutaneous candidiasis

32
Q

If you have periodontitis what happens with neutrophil recruitment?

A

-It is chronic and excessive

33
Q

What happens to osteoclasts in periodontitis?

A

-They become activated

34
Q

What are three ways that mucosal antigens are captured?

A
  • Macrophage
  • Goblet cells
  • Dendritic cells
35
Q

What do commensal bacteria do for an immune response?

A

-Repress

36
Q

What do pathogenic bacteria do for an immune response?

A

-Trigger

37
Q

What cell with mucosal antigens deals with nonspecific transport across epithelium?

A

-M cell

38
Q

T/F Mucosal epithelial cells express TLR and NOD receptors

A

True

39
Q

T/F Epithelial damage can promote mucosal inflammation

A

True (Via antibiotics killing commensal bacteria making room for C. diff)

Host and Defense 2020 (61 decks)

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