4/14/17 Immune system failure GERMAN FINAL TEST Flashcards

1
Q

Pathogen evasion can occur from serotype diversity, what does serotype mean?

A

-Antigenically different strains of the same pathogen

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2
Q

If a person is infected with one serotype of pneumonia and a second serotype infects them later can antibodies prevent infection with the second serotype?

A

No

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3
Q

Pathogen evasion can occur through antigenic drift, what does antigenic drift mean?

A

-Mutations in the viral genome driven by selective pressure as the virus infects a population

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4
Q

Which pathogenic evasion technique is tied to memory erosion?

A

-Antigenic drift

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5
Q

What pathogenic evasion technique is responsible for viral epidemics?

A

-Antigenic drift

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6
Q

What pathogenic evasion technique is useful for tracking outbreaks?

A

-Serotype

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7
Q

Pathogenic evasion can occur through antigenic shift, what does that mean?

A

-Genetic recombination that leads to significant change in viral antigens

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8
Q

What pathogenic evasion technique is responsible for viral pandemics?

A

-Antigenic shift

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9
Q

Recombination of avian and human RNA produces a virus that is an example of what pathogenic evasion technique?

A

-Antigenic shift

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10
Q

T/F Pathogenic evasion can occur through gene conversion

A

True

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11
Q

Pathogenic evasion occurs through latency, what does that mean?

A

-A viral dormant state in host tissue

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12
Q

What is an example latency pathogenic evasion?

A

-Herpes simplex infection

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13
Q

When does recurrent emergence of pathogenic evasion caused by latency occur?

A
  • Stress
  • Concurrent infection
  • Compromised immunity
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14
Q

Subversion can occur for pathogens to survive, What does endocytic hijacking do?

A
  • Utilize endocytosis for entry
  • Prevent lysosome fusion
  • Escape phagosomes
  • Survive autolysosomal environment
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15
Q

Subversion can occur for pathogens to survive, what type of subversion occurs when adult worms coat themselves in host protein?

A

-Antigen mimicry

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16
Q

What are four viral strategies for subversion?

A
  • Inhibition of humoral immunity
  • Inhibition of inflammatory response
  • Blocking of antigen processing and presentation
  • Immunosuppression of host
17
Q

What type of subversion allows for potent toxins that disrupt immune function?

A

-Super antigens

18
Q

What are two examples of gram + bacteria that are superantigens?

A
  • Staph. aureus

- Strep. pyogenes

19
Q

What type of subversion that produce non-specific T cell activation?

A

-Superantigens

20
Q

What type of subversion does antibody and complement inactivation?

A

-Superantigens

21
Q

What type of immunodeficiency is genetically caused immune system deficiency?

A

-Primary immunodeficienty

22
Q

What are three types of primary immunodeficiencies?

A
  • Dominant
  • Recessive
  • X-linked
23
Q

What type of immunodeficiency is caused by environment factors?

A

-Secondary

24
Q

What are four examples of secondary immunodeficiency?

A
  • Chronic disease
  • Immunosuppressive drugs
  • HIV (viral)
  • Environmental toxins
25
Q

What is Bruton’s tyrosine kinase carried on the X-chromosome necessary for?

A

-B cell signalling

26
Q

If you have BTK on males will they develop B cells?

A

-No

27
Q

Do BTK heterozygous females develop B cells?

A

-Yes sort of they have a 50/50 chance depending on which B cells is inactivated, they have to be homozygous for BTK to not develop B cells at 100%

28
Q

What class of primary immunodeficiency has reduced or absent serum immunoglobulin?

A

-Humoral

29
Q

What class of primary immunodeficiency has impaired B cells, and selective IgA deficiency?

A

-Humoral

30
Q

What class of primary immunodeficiency has impaired T cells?

A

-Cellular

31
Q

What class of primary immunodeficiency gives a predisposition to viral, fungal, and opportunistic pathogens?

A

-Cellular

32
Q

What class of primary immunodeficiency gives deficiencies in both B and T cell function such as SCIDS?

A

-Combined

33
Q

What class of primary immunodeficiency has impaired phagocytosis?

A

-Phagocytic

34
Q

What class is Chediak-Higashi syndrome an example of?

A

-Phagocytic

35
Q

What class is DiGeorge syndrome an example of?

A

-Cellular

36
Q

What type of immunodeficiency is HIV?

A

-Secondary

37
Q

How is HIV transmitted?

A
  • Blood

- Sexually

38
Q

What does HIV target?

A

-CD4 T cells