4/13/17 Infectious Hepatitis SPIVAK TEST #3

Question 1

What two types of hepatitis present as acute hepatitis?

Answer 1

A

E

Question 2

What types of hepatitis present as chronic hepatitis?

Answer 2

• B
• C
• D

Question 3

Is acute or chronic hepatitis asymptomatic?

Answer 3

-Chronic

Question 4

Is acute or chronic hepatitis associated with “flu-like” symptoms, fever, myalgias, and pharyngitis?

Answer 4

-Acute

Question 5

Is acute or chronic hepatitis associated with Jaundice, enlarged, and painful liver?

Answer 5

-Acute

Question 6

Does acute or chronic hepatitis resolve spontaneously (on its own)?

Answer 6

-Acute

Question 7

Does acute or chronic hepatitis persist for years or decades?

Answer 7

-Chronic

Question 8

Does acute or chronic hepatitis have marked elevations in LFT (liver function tests)?

Answer 8

-Acute

Question 9

What is the main type of hepatitis that causes chronic hepatitis?

Answer 9

-C

Question 10

What type of hepatitis can cause both chronic and acute hepatitis?

Answer 10

-B

Question 11

Does acute or chronic hepatitis have normal or sometimes elevated LFTs?

Answer 11

-Chronic

Question 12

What type of virus is Hepatitis A?

Answer 12

-Non-enveloped ssRNA virus

Question 13

How is hepatitis A transmitted?

Answer 13

-Fecal-oral route

Question 14

How long does it take for hepatitis A to show symptoms?

Answer 14

-28 days

Question 15

Is polluted water sources a risk for Hep A?

Answer 15

-Yes

Question 16

What is the most common cause of acute hepatitis?

Answer 16

Hep A

Question 17

When does shedding occur for an individual infected with Hep A?

Answer 17

• 1-3 weeks prior to acute hepatitis

- 1 week after onset of jaundice

Question 18

T/F Most adults are asymptomatic when infected with Hep A

Answer 18

• False

- Most children are asymptomatic, but most adults do have symptoms

Question 19

How many vaccine doses are needed for hepatitis A prevention?

Answer 19

-Two doses 6-12 months apart

Question 20

What age should you be when you get vaccinated for Hep A?

Answer 20

-Children at 1 or between the ages of 2-18 if not vaccinated (so basically everyone)

Question 21

What type of virus is Hep E?

Answer 21

-Non-enveloped ssRNA virus

Question 22

T/F Hep E causes acute hepatitis that is clinically indistinguishable from Hep A

Answer 22

True

Question 23

How is Hep E transmitted?

Answer 23

• Spread via fecal contamination of water

- In Endemic areas such as Asia, North Africa, and the middle east

Question 24

What type of virus is Hep B?

Answer 24

-Enveloped DNA virus (partially dsDNA and ssDNA)

Question 25

What is the smallest known human DNA virus?

Answer 25

-Hep B

Question 26

How is Hep B transmitted?

Answer 26

- Perinatal (predominated in areas with high prevalence areas with Hep B) (In utero or as a baby) - Parenteral (most commonly transmitted blood-borne virus in healthcare setting)

Question 27

What is the most commonly transmitted blood-borne virus in healthcare setting?

Answer 27

-Hep B via parenteral

Question 28

T/F There is a vaccine for Hep B

Answer 28

True

Question 29

Out of HBV, HCV, and HIV which is most common to acquire and least common if you get stuck with a needle?

Answer 29

-HBV, HCV, then HIV (least)

Question 30

What is the most common mode of transmission of Hep B in low-prevalence areas?

Answer 30

-Sexually

Question 31

T/F The rate of progression to chronic hepatitis B is inversely correlates with age

Answer 31

True (this means if you are young and get it you will more likely develop chronic hepatitis)

Question 32

In acute hepatitis B is a child that is infected symptomatic or asymptomatic?

Answer 32

-Asymtomatic

Question 33

T/F Men are less likely to have acute flares of Hep B if infected

Answer 33

- False | - Men are more likely to have acute flares

Question 34

T/F Hep B only manifests in the the liver

Answer 34

- False | - It can have extra-hepatic manifestations

Question 35

What places other than the liver can hep B show manifestations?

Answer 35

- Polyarteritis - Membranous nephritis - Aplastic anemia

Question 36

T/F HBV can be associated with cirrhosis and Hepatocellular carcinoma (HCC)

Answer 36

True

Question 37

T/F HCC can develop in chronic HBV in the absence of cirrhosis

Answer 37

True

Question 38

T/F HBeAg is a marker of replication and infectivity

Answer 38

True

Question 39

If you have a vaccine against Hep B what should you find in a blood test?

Answer 39

- + marker for antibody HBs (surface antigen)

Question 40

What antivirals do you use to treat someone with Hep B?

Answer 40

- IFN | - Nucleoside analogs

Question 41

What are the 1st line drugs in the US for treatment of Hep B?

Answer 41

- Tenofovir | - Entecavir

Question 42

What type of virus is Hep D?

Answer 42

-Defective ssRNA virus

Question 43

What type of Hepatitis is a passenger accompanying HBV?

Answer 43

-Hep D

Question 44

How do you treat/manage someone with Hep D?

Answer 44

-IFN alpha (low success rate though)

Question 45

How can you prevent yourself from getting Hep D?

Answer 45

-Be vaccinated against Hep B because it carries Hep D

Question 46

What type of virus is Hep C?

Answer 46

-Enveloped RNA virus

Question 47

How is Hep C transmitted?

Answer 47

-Blood borne transmission

Question 48

If you have a positive HCV ab what does that tell you?

Answer 48

-You have had a past or present infection of Hep C

Question 49

If you have a negative HCV Ab what does that tell you?

Answer 49

-You do not have infection

Question 50

If you have HCV RNA what does that tell you?

Answer 50

-You have Hep C that isn't cleared

Question 51

How many genotypes of Hep C are found worldwide?

Answer 51

-6

Question 52

T/F Hep C has a vaccination

Answer 52

False | -It does not