VAIN (vaginal Intraepithelial Neoplasia)

Question 1

what is VAIN?

Answer 1

vaginal intraepithelial neoplasia
*rare

Question 2

what are the classifications of VAIN?

Answer 2

1: involves basal epithelial layers
2: involves up to 2/3 of vaginal epithelium
3: involves most of vaginal epithelium (carcinoma in situ)

Question 3

who does VAIN affect?

Answer 3

women over 50

Question 4

where is VAIN most commonly located?

Answer 4

upper 1/3 of vagina

Question 5

what is VAIN associated with?

Answer 5

HPV

Question 6

what are the symptoms of VAIN?

Answer 6

asymptomatic until accidental discovery (PALPATION)
- postcoital spotting or vaginal discharge

Question 7

patients who undergo hysterectomy for CIN may develop _________.

Answer 7

VAIN III
- yearly pap after hysterectomy

Question 8

how is VAIN diagnosed?

Answer 8

colposcopy and biopsy
*PERSEVERE vaginal depth

Question 9

what is the treatment for VAIN?
low grade:
high grade:

Answer 9

low: surveillance
high: excision to prevent progression to SCC of the vagina

Question 10

what is the follow up for VAIN?

Answer 10

1. clinical exam every 6 months x 2 years, then annually
2. Cytology + HPV