9.8 Lung Cancer

Question 1

What is the most common cause of cancer mortality in the US?

Answer 1

Lung Cancer

Question 2

What are the key risk factors of lung cancer?

Answer 2

• Smoking
• Asbestos (still more likely to get lung cancer)
• Radon

Question 3

What does imaging reveal in lung cancer patient?

Answer 3

Solitary Nodule - then need to biopsy

Question 4

What are the benign lesions of the lungs?

Answer 4

• Granuloma

- Bronchial Hamartoma

Question 5

What is a hamartoma?

Answer 5

Tumor made of tissue that comes from that tissue

Question 6

What is a lung hamartoma made of?

Answer 6

Cartilage and Lung Tissue

Question 7

What is the most common group of lung carcinoma?

Answer 7

Non-Small Cell Carcinoma

Question 8

What is the treatment for SCC?

Answer 8

Chemotherapy and radiotherapy

“Too small for the surgeon to see”

Question 9

What are the types of NSCLC?

Answer 9

Adenocarcinoma
Squamous Cell
Large Cell

Question 10

SCC Histology

Answer 10

Small cells that are poorly differentiated neuroendocrine tumors

Question 11

SCC Association and Location

Answer 11

Male Smokers

Central in the lung

Question 12

What are some paraneoplastic syndromes that can occur with SCC?

Answer 12

SIADH

ACTH - Cushing’s

Question 13

SQC HIstology

Answer 13

Keratin pearls or intercellular bridges

Question 14

SQC Association and Location

Answer 14

Male Smokers - MOST common tumor in male smokers

Central in the lung

Question 15

What are some paraneoplastic syndrome that can occur with SQC?

Answer 15

PTHrp

Question 16

ADC Histology

Answer 16

Glands or mucin

Question 17

ADC Association and Location

Answer 17

Nonsmokers and Female Smokers

Peripherally found in lung

Question 18

LCC Histology

Answer 18

Poorly differentiated large cells

Question 19

LCC Association and Location

Answer 19

Smoking

Can be central OR peripheral

Question 20

Bronchioalveolar Carcinoma Histology

Answer 20

Columnar cells that grow along preexisting bronchioles and alveoli and arises from Clara cells

Question 21

Bronchioalveolar Carcinoma Association

Answer 21

Not related to smoking

Question 22

Bronchioalveolar Carcinoma Location

Answer 22

Peripheral

Question 23

Carcinoid Tumor Histology

Answer 23

Well differentiated neuroendocrine cells that are chromogranin positive

Question 24

Carcinoid Tumor Association

Answer 24

Not related to smoking

Question 25

Carcinoid Tumor Location

Answer 25

Central or peripheral

Question 26

What will CXR show for metastasized tumors to the lung?

Answer 26

Multiple cannon ball nodules

Question 27

Where do lung cancers tend to metastasize to?

Answer 27

Adrenal Gland

Question 28

What are some of the complications of lung cancer?

Answer 28

• Pleural involvement
• SVC syndrome
• Horner’s Syndrome