9.8 Lung Cancer Flashcards
What is the most common cause of cancer mortality in the US?
Lung Cancer
What are the key risk factors of lung cancer?
- Smoking
- Asbestos (still more likely to get lung cancer)
- Radon
What does imaging reveal in lung cancer patient?
Solitary Nodule - then need to biopsy
What are the benign lesions of the lungs?
- Granuloma
- Bronchial Hamartoma
What is a hamartoma?
Tumor made of tissue that comes from that tissue
What is a lung hamartoma made of?
Cartilage and Lung Tissue
What is the most common group of lung carcinoma?
Non-Small Cell Carcinoma
What is the treatment for SCC?
Chemotherapy and radiotherapy
“Too small for the surgeon to see”
What are the types of NSCLC?
Adenocarcinoma
Squamous Cell
Large Cell
SCC Histology
Small cells that are poorly differentiated neuroendocrine tumors
SCC Association and Location
Male Smokers
Central in the lung
What are some paraneoplastic syndromes that can occur with SCC?
SIADH
ACTH - Cushing’s
SQC HIstology
Keratin pearls or intercellular bridges
SQC Association and Location
Male Smokers - MOST common tumor in male smokers
Central in the lung
What are some paraneoplastic syndrome that can occur with SQC?
PTHrp
ADC Histology
Glands or mucin
ADC Association and Location
Nonsmokers and Female Smokers
Peripherally found in lung
LCC Histology
Poorly differentiated large cells
LCC Association and Location
Smoking
Can be central OR peripheral
Bronchioalveolar Carcinoma Histology
Columnar cells that grow along preexisting bronchioles and alveoli and arises from Clara cells
Bronchioalveolar Carcinoma Association
Not related to smoking
Bronchioalveolar Carcinoma Location
Peripheral
Carcinoid Tumor Histology
Well differentiated neuroendocrine cells that are chromogranin positive
Carcinoid Tumor Association
Not related to smoking
