19.2 Blistering Dermatoses

Question 1

How are blisters formed?

Answer 1

Separation of different layers of the skin

Question 2

Pemphigus Vulgaris

Answer 2

Autoimmune destruction of desmosomes

Question 3

What is the Ab found in pemphigus vulgaris?

Answer 3

IgG Ab against desmoglein

Question 4

What does DIF for IgG look like in pemphigus vulgaris?

Answer 4

Fishnet appearance

Question 5

Where is the blister in pemphigus vulgaris seen?

Answer 5

In the stratum spinosum as the desmosomes are disrupted

Question 6

What are some of the features of pemphigus vulgaris?

Answer 6

• Acantholysis

- Tombstone appearance

Question 7

What attaches the stratum basal to the basement membrane?

Answer 7

Hemidesmosomes

Question 8

What does pemphigus vulgaris affect?

Answer 8

BOTH the skin and oral mucosa

Question 9

Bullous Pemphigoid

Answer 9

Autoimmune destruction of the hemidesmosomes

Question 10

What is the Ab found in bullous pemphigus?

Answer 10

IgG Ab against the basement membrane

Question 11

What does DIF for IgG look like in bullous pemphigus?

Answer 11

Linear IgG Ab

Question 12

Do the bullae in bullous pemphigus rupture easily?

Answer 12

No

Question 13

What does bullous pemphigus affect?

Answer 13

Only the skin. The oral mucosa is spared.

Question 14

Do the bullae in pemphigus vulgaris rupture easily?

Answer 14

Yes

Question 15

Dermatitis Herpetiformis

Answer 15

Autoimmune deposition of IgA at the tips of the dermal papillae and presents as pruritic vesicles and bullae that are grouped

Question 16

What is dermatitis herpetiformis associated with?

Answer 16

Celiac Disease

Question 17

Erythema Multiforme

Answer 17

Hypersensitivity reaction with a targeted rash and bullae

Question 18

What is erythema multiforme associated with?

Answer 18

HSV Infection

Question 19

What is erythema multiforme with oral involvement called?

Answer 19

Stevens Johnson Syndrome

Question 20

Toxic Epidermal Necrolysis

Answer 20

Severe form of SJS that will have diffuse sloughing off of skin resembling a large burn

Question 21

What is often the cause of TEN?

Answer 21

Adverse drug reaction - carbamazepine and lamotrigine are examples