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Pathoma > 6.1 Leukopenia and Leukocytosis > Flashcards

6.1 Leukopenia and Leukocytosis Flashcards

1
Q

What is the marker of hematopoietic stem cells?

A

CD34+

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2
Q

What is the normal WBC count?

A

5000 to 10000

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3
Q

Leukopenia

A

WBC count below 5000

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4
Q

Leukocytosis

A

WBC count above 10000

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5
Q

What are some causes of neutropenia?

A
  • Drug toxicity

- Severe infection

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6
Q

What are some causes of lymphopenia?

A
  • High cortisol state
  • Immunodeficiency
  • Autoimmune destruction
  • Whole body radiation
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7
Q

What are the most sensitive cells in humans to radiation?

A

Lymphocytes

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8
Q

What is a feature of neutrophils released immaturely?

A

Decreased CD16

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9
Q

How does high cortisol cause a neutrophilic leukocytosis?

A

It causes the falling of the marginated pool of neutrophils to fall into the blood as cortisol interferes with the adhesion

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10
Q

What type of leukocytosis is associated with Hodgkin lymphoma?

A

Eosinophilia

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11
Q

How does Hodgkin lymphoma cause eosinophilia?

A

Increased production of IL-5

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12
Q

What is basophilia associated with?

A

Chronic Myelogenous Leukemia

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13
Q

What is the most common cause of lymphocytic leukocytosis?

A

Viral infections

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14
Q

What bacterial infection can cause lymphocytic leukocytosis?

A

Bordatella pertussis

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15
Q

What are the main infection sites of EBV?

A
  • Oropharynx
  • Liver
  • B cells
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16
Q

Where in the lymph nodes are the B cells found?

A

Cortex

17
Q

Where in the lymph nodes are the T cells found?

A

Paracortex

18
Q

What area of the lymph node is expanded with EBV infection?

A

Paracortex - EBV triggers a CD8+ T cell response

19
Q

What Ab are seen with EBV infection?

A

IgM Heterophile Antibodies

20
Q

What can cause infectious mononucleosis but will have a negative mono spot test?

A

CMV

21
Q

What are patients with infectious mononucleosis at increased risk for?

A

Splenic Rupture

Pathoma (119 decks)

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