19.3 Epithelial Tumors Flashcards
Seborrheic Keratosis
Benign squamous proliferation that is common in the elderly and is a raised lesion with a “stuck-on” appearance
Leser-Trelat Sign
Sudden onset of multiple seborrheic keratosis that is indicative of an underlying carcinoma - usually GI
Acanthosis Nigricans
Epidermal hyperplasia with darkening of the skin usually in the groin or axilla
What is acanthosis nigricans often associated with?
- Insulin Resistance
- Malignancy
Basal Cell Carcinoma
Malignant proliferation of basal cells of the epidermis
What are the risk factors of BCC?
- Sun exposure (mainly UVB)
- Albinism
- Xeroderma Pigmentosum
Xeroderma Pigmentosum
Mutations in the nucleotide excision repair pathway - increased risk of BCC
What is the classical location of BCC?
Upper Lip
What is a classic finding on histology of BCC?
Peripheral palisading cells
What is the treatment and prognosis of BCC?
Surgical excision with excellent prognosis
Actinic Keratosis
Precursor to SCC that presents as hyperkeratotic scaly plaque
What are the risk factors of SCC?
- Sun exposure (mainly UVB)
- Albinism
- Xeroderma Pigmentosum
- Immunosuppression
- Arsenic
- Chronic Inflammation
What is the most common cancer that results from immunosuppression?
SCC of the skin
Where is SCC generally found?
On the face - involves the lower lip
Keratoacanthoma
Well differentiated SCC that develops rapidly and regresses spontaneously
