2.2 Chronic Inflammation Flashcards
1
Q
What is the hallmark of chronic inflammation?
A
Lymphocytes and plasma cells in the tissue
Macrophages in particular are present as well
2
Q
What do CD4+ cells recognize?
A
MHC Class 2
3
Q
What do CD8+ cells recognize?
A
MHC Class 1
4
Q
What do T cells require for activation?
A
- MHC presentation of Ag
- B7 on the APC binding to CD28 on the CD4+ T cells
5
Q
What can cause non-caseating granulomas?
A
- Reaction to foreign material
- Sarcoidosis
- Beryllium Exposure
- Crohn’s Disease
6
Q
What is a giant cell?
A
A multinucleate cell with abundant cytoplasm
7
Q
What is a caseating granuloma characteristic of?
A
- TB
- Fungal infection
