15.6 Thyroiditis

Question 1

Hashimoto Thyroiditis

Answer 1

Autoimmune destruction of the thyroid gland

Question 2

What gene is Hashimoto thyroiditis associated with?

Answer 2

HLA-DR5

Question 3

What are the features of Hashimoto disease?

Answer 3

Initial hyperthyroid presentation that progresses to hypothyroidism.

• Decreased T4
• Increased TSH
• Antithyroglobulin Ab
• Antimicrosomal Ab

Question 4

What are the histological changes of Hashimoto disease?

Answer 4

Chronic inflammation with the formation of germinal centers and the appearance of Hurthle cells.

Question 5

What are patients with Hashimoto disease at increased risk for?

Answer 5

B-cell Lymphoma

Question 6

Subacute deQuervain Granulomatous Thyroiditis

Answer 6

Granulomatous thyroiditis that follows a viral infection

Question 7

What is the presentation of subacute deQuervain granulomatous thyroiditis?

Answer 7

Tender thyroid with transient hyperthyroidism - self limited

Question 8

Reidel Fibrosing Thyroiditis

Answer 8

Chronic inflammation with excessive fibrosis of thyroid

Question 9

How does Reidel fibrosing thyroiditis present?

Answer 9

Hypothyroidism with “hard as wood” thyroid - fibrosis can spread to airway

Question 10

Who is the classical patient of Reidel fibrosing thyroiditis?

Answer 10

Young female